Two-component systems required for virulence in Pseudomonas aeruginosa
dc.contributor.author | Francis, VI | |
dc.contributor.author | Stevenson, EC | |
dc.contributor.author | Porter, SL | |
dc.date.accessioned | 2017-05-10T15:09:54Z | |
dc.date.issued | 2017-05-16 | |
dc.description.abstract | Pseudomonas aeruginosa is a versatile opportunistic pathogen capable of infecting a broad range of hosts, in addition to thriving in a broad range of environmental conditions outside of hosts. With this versatility comes the need to tightly regulate its genome to optimise its gene expression and behaviour to the prevailing conditions. Two-component systems (TCSs) comprising sensor kinases and response regulators, play a major role in this regulation. This minireview discusses the growing number of two-component systems that have been implicated in the virulence of Pseudomonas aeruginosa, with a special focus on the emerging theme of multikinase networks, which are networks comprising multiple sensor kinases working together, sensing and integrating multiple signals to decide upon the best response. The networks covered in depth regulate processes such as the switch between acute and chronic virulence (GacS network), the Cup fimbriae (Roc network and Rcs/Pvr network), the aminoarabinose modification of lipopolysaccharide (a network involving the PhoQP and PmrBA TCSs), twitching motility and virulence (a network formed from the Chp chemosensory pathway and the FimS/AlgR TCS), and biofilm formation (Wsp chemosensory pathway). In addition, we highlight the important interfaces between these systems and secondary messenger signals such as cAMP and c-di-GMP. | en_GB |
dc.description.sponsorship | This work was supported by the Medical Research Council (MRC) [grant number MR/M020045/1], the Leverhulme Trust [grant number RPG-2014-228] and the RoseTrees Trust [grant number M328]. | en_GB |
dc.identifier.doi | https://doi.org/10.1093/femsle/fnx104 | |
dc.identifier.uri | http://hdl.handle.net/10871/27463 | |
dc.language.iso | en | en_GB |
dc.publisher | Oxford University Press (OUP) for Federation of European Microbiological Societies | en_GB |
dc.rights | © FEMS 2017. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. | |
dc.subject | Two-component signalling | en_GB |
dc.subject | multikinase network | en_GB |
dc.subject | Pseudomonas aeruginosa | en_GB |
dc.subject | secondary messengers | en_GB |
dc.subject | virulence | en_GB |
dc.title | Two-component systems required for virulence in Pseudomonas aeruginosa | en_GB |
dc.type | Article | en_GB |
dc.identifier.issn | 0378-1097 | |
dc.description | This is the author accepted manuscript. The final version is available from Oxford University Press via the DOI in this record. | |
dc.identifier.journal | FEMS Microbiology Letters | en_GB |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.