dc.contributor.author | Smith, AR | |
dc.contributor.author | Mill, J | |
dc.contributor.author | Smith, RG | |
dc.contributor.author | Lunnon, K | |
dc.date.accessioned | 2017-05-17T09:50:06Z | |
dc.date.issued | 2016-05-14 | |
dc.description.abstract | © 2016 The Authors.Alzheimer's disease is a complex neurodegenerative disorder. A large number of genome-wide association studies have been performed, which have been supplemented more recently by the first epigenome-wide association studies, leading to the identification of a number of novel loci altered in disease. Twin studies have shown monozygotic twin discordance for Alzheimer's disease (Gatz et al., 2006), leading to the conclusion that a combination of genetic and epigenetic mechanisms is likely to be involved in disease etiology (Lunnon & Mill, 2013). This review focuses on identifying overlapping pathways between published genome-wide association studies and epigenome-wide association studies, highlighting dysfunctional synaptic, lipid metabolism, plasma membrane/cytoskeleton, mitochondrial, and immune cell activation pathways. Identifying common pathways altered in genetic and epigenetic studies will aid our understanding of disease mechanisms and identify potential novel targets for pharmacological intervention. | en_GB |
dc.description.sponsorship | This work was funded by a grant from Bristol Research into Alzheimer's and Care of the Elderly and the Alzheimer's Society (grant AS-PG-14-038) to KL. | en_GB |
dc.identifier.citation | Vol. 6, June 2016, pp. 32 - 50 | en_GB |
dc.identifier.doi | 10.1016/j.nepig.2016.05.001 | |
dc.identifier.uri | http://hdl.handle.net/10871/27556 | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.rights | (c) 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en_GB |
dc.subject | Alzheimer's disease | en_GB |
dc.subject | AD | en_GB |
dc.subject | DNA methylation | en_GB |
dc.subject | GWAS | en_GB |
dc.subject | EWAS | en_GB |
dc.subject | Exome sequencing | en_GB |
dc.title | Elucidating novel dysfunctional pathways in Alzheimer's disease by integrating loci identified in genetic and epigenetic studies | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2017-05-17T09:50:06Z | |
dc.identifier.issn | 2214-7845 | |
dc.description | Published | en_GB |
dc.description | Review | en_GB |
dc.description | Journal | en_GB |
dc.description | This is the author accepted manuscript. The final version is freely available from Elsevier via the DOI in this record. | en_GB |
dc.identifier.eissn | 2214-7845 | |
dc.identifier.journal | Neuroepigenetics | en_GB |