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dc.contributor.authorTitball, RW
dc.contributor.authorBurtnick, MN
dc.contributor.authorBancroft, GJ
dc.contributor.authorBrett, P
dc.date.accessioned2017-06-01T12:53:13Z
dc.date.issued2017-03-21
dc.description.abstractB. pseudomallei is the cause of melioidosis, a serious an often fatal disease of humans and animals. The closely related bacterium B. mallei, which cases glanders, is considered to be a clonal derivative of B. pseudomallei. Both B. pseudomallei and B. mallei were evaluated by the United States and the former USSR as potential bioweapons. Much of the effort to devise biodefence vaccines in the past decade has been directed towards the identification and formulation of sub-unit vaccines which could protect against both melioidosis and glanders. A wide range of proteins and polysaccharides have been identified which protective immunity in mice. In this review we highlight the significant progress that has been made in developing glycoconjugates as sub-unit vaccines. We also consider some of the important the criteria for licensing, including the suitability of the "animal rule" for assessing vaccine efficacy, the protection required from a vaccine and the how correlates of protection will be identified. Vaccines developed for biodefence purposes could also be used in regions of the world where naturally occurring disease is endemic.en_GB
dc.identifier.citationVol. 35 (44), pp. 5981-5989en_GB
dc.identifier.doi10.1016/j.vaccine.2017.03.022
dc.identifier.urihttp://hdl.handle.net/10871/27758
dc.language.isoenen_GB
dc.publisherElsevieren_GB
dc.rights.embargoreasonUnder embargo until 21 March 2018 in compliance with publisher policyen_GB
dc.subjectMelioidosisen_GB
dc.subjectBiowarfareen_GB
dc.subjectBioterrorismen_GB
dc.subjectVaccineen_GB
dc.titleBurkholderia pseudomallei and Burkholderia mallei vaccines: Are we close to clinical trials?en_GB
dc.typeArticleen_GB
dc.identifier.issn0264-410X
dc.descriptionThis is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.en_GB
dc.identifier.journalVaccineen_GB


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