dc.contributor.author | Fernandes da Costa, SP | |
dc.contributor.author | Mot, D | |
dc.contributor.author | Geeraerts, S | |
dc.contributor.author | Bokori-Brown, M | |
dc.contributor.author | Van Immerseel, F | |
dc.contributor.author | Titball, RW | |
dc.date.accessioned | 2017-06-12T10:31:36Z | |
dc.date.issued | 2016-06 | |
dc.description.abstract | Necrotic enteritis toxin B (NetB) is a pore-forming toxin produced by Clostridium perfringens and has been shown to play a key role in avian necrotic enteritis, a disease causing significant costs to the poultry production industry worldwide. The aim of this work was to determine whether immunization with a non-toxic variant of NetB (NetB W262A) and the C-terminal fragment of C. perfringens alpha-toxin (CPA247-370) would provide protection against experimental necrotic enteritis. Immunized birds with either antigen or a combination of antigens developed serum antibody levels against NetB and CPA. When CPA247-370 and NetB W262A were used in combination as immunogens, an increased protection was observed after oral challenge by individual dosing, but not after in-feed-challenge. | en_GB |
dc.identifier.citation | Vol. 45, pp. 381 - 388 | en_GB |
dc.identifier.doi | 10.1080/03079457.2015.1129663 | |
dc.identifier.uri | http://hdl.handle.net/10871/27948 | |
dc.language.iso | en | en_GB |
dc.publisher | Taylor & Francis (Routledge) | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/26743457 | en_GB |
dc.rights | © 2016 The Author(s). Published by Informa
UK Limited, trading as Taylor & Francis
Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted
use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_GB |
dc.subject | Clostridium perfringens | en_GB |
dc.subject | NetB | en_GB |
dc.subject | alpha-toxin | en_GB |
dc.subject | immunization | en_GB |
dc.subject | necrotic enteritis | en_GB |
dc.title | Variable protection against experimental broiler necrotic enteritis after immunization with the C-terminal fragment of Clostridium perfringens alpha-toxin and a non-toxic NetB variant | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2017-06-12T10:31:36Z | |
dc.identifier.issn | 0307-9457 | |
exeter.place-of-publication | England | en_GB |
dc.description | This is the final version of the article. Available from the publisher via the DOI in this record. | en_GB |
dc.identifier.journal | Avian Pathology | en_GB |
dc.identifier.pmid | 26743457 | |