Seven newly identified loci for autoimmune thyroid disease
Wellcome Trust Case Control Consortium
Human Molecular Genetics
Oxford University Press (OUP)
© The Author 2012. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), is one of the most common of the immune-mediated diseases. To further investigate the genetic determinants of AITD, we conducted an association study using a custom-made single-nucleotide polymorphism (SNP) array, the ImmunoChip. The SNP array contains all known and genotype-able SNPs across 186 distinct susceptibility loci associated with one or more immune-mediated diseases. After stringent quality control, we analysed 103 875 common SNPs (minor allele frequency >0.05) in 2285 GD and 462 HT patients and 9364 controls. We found evidence for seven new AITD risk loci (P < 1.12 × 10(-6); a permutation test derived significance threshold), five at locations previously associated and two at locations awaiting confirmation, with other immune-mediated diseases.
The research leading to these results has received funding from the European Union’s 7th Framework Programme (FP7/2007– 2013) under grant agreement No. 241447 [Natural immunomodulators as novel immunotherapies for type 1 diabetes (NAIMIT)]. Funding to pay the Open Access publication charges for this article was provided by the Wellcome Trust.
This is the final version of the article. Available from the publisher via the DOI in this record.
Vol. 21, pp. 5202 - 5208
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