Seven newly identified loci for autoimmune thyroid disease
Wellcome Trust Case Control Consortium
Human Molecular Genetics
Oxford University Press (OUP)
© The Author 2012. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), is one of the most common of the immune-mediated diseases. To further investigate the genetic determinants of AITD, we conducted an association study using a custom-made single-nucleotide polymorphism (SNP) array, the ImmunoChip. The SNP array contains all known and genotype-able SNPs across 186 distinct susceptibility loci associated with one or more immune-mediated diseases. After stringent quality control, we analysed 103 875 common SNPs (minor allele frequency >0.05) in 2285 GD and 462 HT patients and 9364 controls. We found evidence for seven new AITD risk loci (P < 1.12 × 10(-6); a permutation test derived significance threshold), five at locations previously associated and two at locations awaiting confirmation, with other immune-mediated diseases.
The research leading to these results has received funding from the European Union’s 7th Framework Programme (FP7/2007– 2013) under grant agreement No. 241447 [Natural immunomodulators as novel immunotherapies for type 1 diabetes (NAIMIT)]. Funding to pay the Open Access publication charges for this article was provided by the Wellcome Trust.
This is the final version of the article. Available from the publisher via the DOI in this record.
Vol. 21, pp. 5202 - 5208
PubMed Central ID
Place of publication
Showing items related by title, author, creator and subject.
Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies. Catalá-López, F; Hutton, B; Driver, JA; Page, MJ; Ridao, M; Valderas, JM; Alonso-Arroyo, A; Forés-Martos, J; Martínez, S; Gènova-Maleras, R; Macías-Saint-Gerons, D; Crespo-Facorro, B; Vieta, E; Valencia, A; Tabarés-Seisdedos, R (BioMed Central, 2017-04-04)BACKGROUND: The objective of this study will be to synthesize the epidemiological evidence and evaluate the validity of the associations between central nervous system disorders and the risk of developing or dying from ...
Inverse and Direct Cancer Comorbidity in People with Central Nervous System Disorders: A Meta-Analysis of Cancer Incidence in 577,013 Participants of 50 Observational Studies Catala-Lopez, F; Suarez-Pinilla, M; Suarez-Pinilla, P; Valderas, JM; Gomez-Beneyto, M; Martinez, S; Balanza-Martinez, V; Climent, J; Valencia, A; McGrath, J; Crespo-Facorro, B; Sanchez-Moreno, J; Vieta, E; Tabares-Seisdedos, R (Karger, 2014-01-22)Background: There is a lack of scientific consensus about cancer comorbidity in people with central nervous system (CNS) disorders. This study assesses the co-occurrence of cancers in patients with CNS disorders, including ...
Staley, M.; Bonneaud, Camille (Wiley, 2015-04-27)Over the past several decades, outbreaks of emerging infectious diseases (EIDs) in wild birds have attracted worldwide media attention, either because of their extreme virulence or because of alarming spillovers into ...