The Drosophila simulans Y chromosome interacts with the autosomes to influence male fitness.
Journal of Evolutionary Biology
Reason for embargo
The Y chromosome should degenerate because it cannot recombine. However, male limited transmission increases selection efficiency for male benefit alleles on the Y, and therefore Y-chromosomes should contribute significantly to variation in male-fitness. This means that although the Drosophila Y chromosome is small and gene-poor, Y-linked genes are vital for male fertility in D. melanogaster and the Y chromosome has large male-fitness effects. It is unclear if the same pattern is seen in the closely related D. simulans. We backcrossed Y chromosomes from 3 geographic locations into 5 genetic backgrounds and found strong Y and genetic background effects on male fertility. There was a significant Y-background interaction, indicating substantial epistasis between the Y and autosomal genes affecting male fertility. This supports accumulating evidence that interactions between the Y chromosome and the autosomes are key determinants of male fitness. This article is protected by copyright. All rights reserved.
DJH was funded by The Leverhulme Trust.
This is the author's accepted manuscript
The final version is available from Wiley via the DOI in this record
Accepted manuscript online 13 July 2017
Place of publication