dc.contributor.author | Adepu, S | |
dc.contributor.author | Gaydhane, MK | |
dc.contributor.author | Kakunuri, M | |
dc.contributor.author | Sharma, CS | |
dc.contributor.author | Khandelwal, M | |
dc.contributor.author | Eichhorn, SJ | |
dc.date.accessioned | 2017-08-24T14:42:04Z | |
dc.date.issued | 2017-07-24 | |
dc.description.abstract | Sustained release and prevention of burst release for low half-life drugs like Diclofenac sodium is crucial to prevent drug related toxicity. Electrospun nanofibers have emerged recently as potential carrier materials for controlled and sustained drug release. Here, we present a facile method to prevent burst release by tuning the surface wettability through template assisted micropatterning of drug loaded electrospun cellulose acetate (CA) nanofibers. A known amount of drug (Diclofenac sodium) was first mixed with CA and then electrospun in the form of a nanofabric. This as-spun network was hydrophilic in nature. However, when electrospinning was carried out through non-conducting templates, viz nylon meshes with 50 and 100 μm size openings, two kinds of hydrophobic micro-patterned CA nanofabrics were produced. In vitro transdermal testing of our nanofibrous mats was carried out; these tests were able to show that it would be possible to create a patch for transdermal drug release. Further, our results show that with optimized micro-patterned dimensions, a zero order sustained drug release of up to 12 h may be achieved for the transdermal system when compared to non-patterned samples. This patterning caused a change in the surface wettability, to a hydrophobic surface, resulting in a controlled diffusion of the hydrophilic drug. Patterning assisted in controlling the initial burst release, which is a significant finding especially for low half-life drugs. | en_GB |
dc.description.sponsorship | Authors acknowledge the support of DST-UKIERI grant (IND/CONT/E/14-15/370 & DST/INT/UK/P-92/14). | en_GB |
dc.identifier.citation | Vol. 426, pp. 755 - 762 | en_GB |
dc.identifier.doi | 10.1016/j.apsusc.2017.07.197 | |
dc.identifier.uri | http://hdl.handle.net/10871/29060 | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.rights.embargoreason | Publisher policy | en_GB |
dc.subject | Drug release | en_GB |
dc.subject | Electrospinning | en_GB |
dc.subject | Nanofibers | en_GB |
dc.subject | Micro-patterning | en_GB |
dc.subject | Diclofenac sodium | en_GB |
dc.title | Effect of micropatterning induced surface hydrophobicity on drug release from electrospun cellulose acetate nanofibers | en_GB |
dc.type | Article | en_GB |
dc.identifier.issn | 0169-4332 | |
dc.description | This is the author's accepted manuscript | en_GB |
dc.description | Final version available from Elsevier via the DOI in this record | en_GB |
dc.identifier.journal | Applied Surface Science | en_GB |