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dc.contributor.authorTabish, TA
dc.contributor.authorChabi, S
dc.contributor.authorAli, M
dc.contributor.authorXia, Y
dc.contributor.authorJabeen, F
dc.contributor.authorZhang, S
dc.date.accessioned2017-11-10T14:47:11Z
dc.date.issued2017-03-24
dc.description.abstractGraphene-based materials with a three-dimensional (3D) framework have been investigated for a variety of biomedical applications because of their 3D morphology, excellent physiochemical properties, volume stability, and their controllable degradation rate. Current knowledge on the toxicological implications and bioavailability of graphene foam (GF) has major uncertainties surrounding the fate and behavior of GF in exposed environments. Bioavailability, uptake, and partitioning could have potential effects on the behavior of GF in living organisms, which has not yet been investigated. Here, we report a pilot toxicology study on 3D GF in common carps. Our results showed that GF did not show any noticeable toxicity in common carps, and the antioxidant enzymatic activities, biochemical and blood parameters persisted within the standard series. Further histological imaging revealed that GF remained within liver and kidney macrophages for 7 days without showing obvious toxicity. An in vivo study also demonstrated a direct interaction between GF and biological systems, verifying its eco-friendly nature and high biocompatibility.en_GB
dc.description.sponsorshipThis work was supported by EPSRC Centre for Doctoral Training in Metamaterials, XM2 (Grant No. EP/L015331/1) University of Exeter EX4 4QF, United Kingdom.en_GB
dc.identifier.citationVol. 10 (4), article 336en_GB
dc.identifier.doi10.3390/ma10040336
dc.identifier.urihttp://hdl.handle.net/10871/30264
dc.language.isoenen_GB
dc.publisherMDPIen_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/28772699en_GB
dc.rights© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).en_GB
dc.subjectbioavailabilityen_GB
dc.subjectbiological tissuesen_GB
dc.subjectfishen_GB
dc.subjectgraphene foamen_GB
dc.titleTracing the Bioavailability of Three-Dimensional Graphene Foam in Biological Tissuesen_GB
dc.typeArticleen_GB
dc.date.available2017-11-10T14:47:11Z
dc.identifier.issn1996-1944
exeter.place-of-publicationSwitzerlanden_GB
dc.descriptionThis is the final version of the article. Available from MDPI via the DOI in this record.en_GB
dc.identifier.journalMaterialsen_GB


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