dc.contributor.author | Cockcroft, EJ | |
dc.contributor.author | Williams, CA | |
dc.contributor.author | Jackman, SR | |
dc.contributor.author | Armstrong, N | |
dc.contributor.author | Barker, AR | |
dc.date.accessioned | 2017-11-28T11:55:23Z | |
dc.date.issued | 2017-05-08 | |
dc.description.abstract | Assessment of plasma insulin and glucose outcomes is important in paediatric studies aimed at reducing future risk of type 2 diabetes and cardiovascular disease. The aims of this study are to determine the between-method agreement and the day-to-day reliability of fasting and oral glucose tolerance test (OGTT)-derived estimates of insulin sensitivity and β-cell function in healthy boys. Fasting and OGTT assesments of insulin resistance and β-cell function were performed on 28 boys (12.3±2.9 years). Measurements were repeated after 1 week (fasting, n=28) and 1 day (OGTT, n=8). Agreement between estimates of insulin resistance and β-cell function was examined using Pearson's correlation coefficient. Reliability was assessed using change in the mean, Pearson's correlation coefficient, and typical error expressed as a coefficient of variation (CV). The Matsuda index was positively related with QUICKI (r=0.88, P<0.001) and negatively related to HOMA-IR (r=-0.76, P<0.001). The Cederholm index was not significantly related with fasting estimates of insulin resistance (all r<0.40, P>0.05). For reliability, QUICKI had the lowest CV% for the fasting (4.7%) and the Cederholm index for the OGTT (6.4%) estimates. The largest CV% was observed in fasting insulin (30.8%) and insulinogenic index 30' (62.5%). This study highlights differences in between-method agreement and day-to-day reliability for estimates of insulin resistance in youth. The low CV supports the use of the FGIR (fasting) and Cederholm (OGTT) indices in this population. | en_GB |
dc.identifier.citation | Vol. 38 (6), pp. 411 - 417 | en_GB |
dc.identifier.doi | 10.1055/s-0043-104932 | |
dc.identifier.uri | http://hdl.handle.net/10871/30488 | |
dc.publisher | Thieme Publishing | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/28482366 | en_GB |
dc.rights.embargoreason | Publisher policy | en_GB |
dc.subject | insulin sensitivity | en_GB |
dc.subject | youth | en_GB |
dc.subject | type two diabetes | en_GB |
dc.title | Agreement and Reliability of Fasted and Oral Glucose Tolerance Test-Derived Indices of Insulin Sensitivity and Beta Cell Function in Boys | en_GB |
dc.type | Article | en_GB |
exeter.place-of-publication | Germany | en_GB |
dc.description | This is the author accepted manuscript. The final version is available from Thieme Publishing via the DOI in this record. | en_GB |
dc.identifier.journal | International Journal of Sports Medicine | en_GB |