dc.contributor.author | Aizawa, K | |
dc.contributor.author | Elyas, S | |
dc.contributor.author | Adingupu, DD | |
dc.contributor.author | Casanova, F | |
dc.contributor.author | Gooding, KM | |
dc.contributor.author | Shore, AC | |
dc.contributor.author | Strain, WD | |
dc.contributor.author | Gates, PE | |
dc.date.accessioned | 2017-12-08T15:35:05Z | |
dc.date.issued | 2016-03-02 | |
dc.description.abstract | The grey-scale median of the common carotid artery intima-media complex (IM-GSM) characterizes arterial wall composition, and a low IM-GSM is associated with increased cardiovascular mortality in the elderly. We aimed to determine differences in the IM-GSM between a cohort with cerebrovascular disease and a healthy cohort. Eighty-two healthy individuals (control group: 63.2 ± 8.7 y) and 96 patients with either stroke or transient ischemic attacks (CRVD group: 68.6 ± 9.8 y) were studied. Common carotid artery intima-media thickness and IM-GSM obtained by ultrasound were analyzed using semi-automated edge-detection software. The IM-GSM was significantly lower in the CRVD group than in the control group (106 ± 24 vs. 124 ± 27 au, p < 0.001). The IM-GSM was similar for the infarct and non-infarct sides in CRVD. In the pooled cohort of all participants, the lower the quartile of IM-GSM, the greater were the carotid artery intima-media thickness and carotid artery remodeling. These results suggest the presence of an altered atherosclerotic phenotype in the intima-media complex of CRVD patients that can be detected by ultrasound. | en_GB |
dc.description.sponsorship | This study was supported in part by the NIHR Exeter Clinical Research Facility | en_GB |
dc.identifier.citation | Vol. 42 (5), pp. 1130 - 1137 | en_GB |
dc.identifier.doi | 10.1016/j.ultrasmedbio.2016.01.006 | |
dc.identifier.uri | http://hdl.handle.net/10871/30608 | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier for World Federation for Ultrasound in Medicine and Biology | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/26944528 | en_GB |
dc.subject | Carotid artery | en_GB |
dc.subject | Echogenicity | en_GB |
dc.subject | Intima–media thickness | en_GB |
dc.subject | Stroke | en_GB |
dc.subject | Ultrasound | en_GB |
dc.subject | Adult | en_GB |
dc.subject | Carotid Intima-Media Thickness | en_GB |
dc.subject | Carotid Stenosis | en_GB |
dc.subject | Female | en_GB |
dc.subject | Humans | en_GB |
dc.subject | Image Interpretation, Computer-Assisted | en_GB |
dc.subject | Male | en_GB |
dc.subject | Reproducibility of Results | en_GB |
dc.subject | Sensitivity and Specificity | en_GB |
dc.subject | Stroke | en_GB |
dc.title | Echogenicity of the Common Carotid Artery Intima-Media Complex in Stroke | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2017-12-08T15:35:05Z | |
exeter.place-of-publication | England | en_GB |
dc.description | This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record. | en_GB |
dc.identifier.journal | Ultrasound in Medicine and Biology | en_GB |