dc.contributor.author | Liew, N | |
dc.contributor.author | Mazon Moya, MJ | |
dc.contributor.author | Wierzbicki, CJ | |
dc.contributor.author | Hollinshead, M | |
dc.contributor.author | Dillon, MJ | |
dc.contributor.author | Thornton, CR | |
dc.contributor.author | Ellison, A | |
dc.contributor.author | Cable, J | |
dc.contributor.author | Fisher, MC | |
dc.contributor.author | Mostowy, S | |
dc.date.accessioned | 2017-12-12T13:00:15Z | |
dc.date.issued | 2017-04-20 | |
dc.description.abstract | Aquatic chytrid fungi threaten amphibian biodiversity worldwide owing to their ability to rapidly expand their geographical distributions and to infect a wide range of hosts. Combating this risk requires an understanding of chytrid host range to identify potential reservoirs of infection and to safeguard uninfected regions through enhanced biosecurity. Here we extend our knowledge on the host range of the chytrid Batrachochytrium dendrobatidis by demonstrating infection of a non-amphibian vertebrate host, the zebrafish. We observe dose-dependent mortality and show that chytrid can infect and proliferate on zebrafish tissue. We also show that infection phenotypes (fin erosion, cell apoptosis and muscle degeneration) are direct symptoms of infection. Successful infection is dependent on disrupting the zebrafish microbiome, highlighting that, as is widely found in amphibians, commensal bacteria confer protection against this pathogen. Collectively, our findings greatly expand the limited tool kit available to study pathogenesis and host response to chytrid infection. | en_GB |
dc.description.sponsorship | N.L. is supported by the Lister Institute of Preventive Medicine. J.C. and A.E. were funded by the Welsh Government and Higher Education Funding Council for Wales through the Sêr Cymru National Research Network for Low Carbon, Energy and Environment AquaWales Project. C.R.T. and M.J.D. were funded by the Leverhulme Trust. Work in the Fisher laboratory is supported by the UK Natural Environmental Research Council (NERC NE/K014455/1) and the Leverhulme Trust. Work in the Mostowy laboratory is supported by a Wellcome Trust Research Career Development Fellowship (WT097411MA) and the Lister Institute of Preventive Medicine. | en_GB |
dc.identifier.citation | Vol. 8, article 15048 | en_GB |
dc.identifier.doi | 10.1038/ncomms15048 | |
dc.identifier.uri | http://hdl.handle.net/10871/30647 | |
dc.language.iso | en | en_GB |
dc.publisher | Springer Nature | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/28425465 | en_GB |
dc.rights | © The Author(s) 2017. Open access. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | en_GB |
dc.subject | Ecological epidemiology | en_GB |
dc.subject | Fungal pathogenesis | en_GB |
dc.subject | Pathogens | en_GB |
dc.title | Chytrid fungus infection in zebrafish demonstrates that the pathogen can parasitize non-amphibian vertebrate hosts | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2017-12-12T13:00:15Z | |
exeter.place-of-publication | England | en_GB |
dc.description | This is the final version of the article. Available from Springer Nature via the DOI in this record. | en_GB |
dc.identifier.journal | Nature Communications | en_GB |