dc.contributor.author | Fleming, LE | |
dc.contributor.author | Kirkpatrick, B | |
dc.contributor.author | Backer, LC | |
dc.contributor.author | Bean, JA | |
dc.contributor.author | Wanner, A | |
dc.contributor.author | Dalpra, D | |
dc.contributor.author | Tamer, R | |
dc.contributor.author | Zaias, J | |
dc.contributor.author | Cheng, YS | |
dc.contributor.author | Pierce, R | |
dc.contributor.author | Naar, J | |
dc.contributor.author | Abraham, W | |
dc.contributor.author | Clark, R | |
dc.contributor.author | Zhou, Y | |
dc.contributor.author | Henry, MS | |
dc.contributor.author | Johnson, D | |
dc.contributor.author | Van De Bogart, G | |
dc.contributor.author | Bossart, GD | |
dc.contributor.author | Harrington, M | |
dc.contributor.author | Baden, DG | |
dc.date.accessioned | 2018-01-02T11:51:30Z | |
dc.date.issued | 2005-05 | |
dc.description.abstract | Florida red tides annually occur in the Gulf of Mexico, resulting from blooms of the marine dinoflagellate Karenia brevis. K. brevis produces highly potent natural polyether toxins, known as brevetoxins, that activate voltage-sensitive sodium channels. In experimental animals, brevetoxins cause significant bronchoconstriction. A study of persons who visited the beach recreationally found a significant increase in self-reported respiratory symptoms after exposure to aerosolized Florida red tides. Anecdotal reports indicate that persons with underlying respiratory diseases may be particularly susceptible to adverse health effects from these aerosolized toxins. Fifty-nine persons with physician-diagnosed asthma were evaluated for 1 hr before and after going to the beach on days with and without Florida red tide. Study participants were evaluated with a brief symptom questionnaire, nose and throat swabs, and spirometry approved by the National Institute for Occupational Safety and Health. Environmental monitoring, water and air sampling (i.e., K. brevis, brevetoxins, and particulate size distribution), and personal monitoring (for toxins) were performed. Brevetoxin concentrations were measured by liquid chromatography mass spectrometry, high-performance liquid chromatography, and a newly developed brevetoxin enzyme-linked immunosorbent assay. Participants were significantly more likely to report respiratory symptoms after Florida red tide exposure. Participants demonstrated small but statistically significant decreases in forced expiratory volume in 1 sec, forced expiratory flow between 25 and 75%, and peak expiratory flow after exposure, particularly those regularly using asthma medications. Similar evaluation during nonexposure periods did not significantly differ. This is the first study to show objectively measurable adverse health effects from exposure to aerosolized Florida red tide toxins in persons with asthma. Future studies will examine the possible chronic effects of these toxins among persons with asthma and other chronic respiratory impairment. | en_GB |
dc.description.sponsorship | This research was supported by National Institute of
Environmental Health Sciences (NIEHS) grant P01
ES 10594 and a Minority Supplement to the P01 also
from the NIEHS, as well as by the Centers for Disease
Control and Prevention, the Florida Harmful Bloom
Taskforce, and the Florida Department of Health. | en_GB |
dc.identifier.citation | Vol. 113 (5), pp. 650 - 657 | en_GB |
dc.identifier.doi | 10.1289/ehp.7500 | |
dc.identifier.uri | http://hdl.handle.net/10871/30787 | |
dc.language.iso | en | en_GB |
dc.publisher | National Institute of Environmental Health Sciences (NIEHS) | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/15866779 | en_GB |
dc.rights | Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. | en_GB |
dc.subject | Adolescent | en_GB |
dc.subject | Adult | en_GB |
dc.subject | Aerosols | en_GB |
dc.subject | Aged | en_GB |
dc.subject | Animals | en_GB |
dc.subject | Asthma | en_GB |
dc.subject | Child | en_GB |
dc.subject | Chromatography, High Pressure Liquid | en_GB |
dc.subject | Dinoflagellida | en_GB |
dc.subject | Female | en_GB |
dc.subject | Florida | en_GB |
dc.subject | Humans | en_GB |
dc.subject | Inhalation Exposure | en_GB |
dc.subject | Male | en_GB |
dc.subject | Marine Toxins | en_GB |
dc.subject | Mass Spectrometry | en_GB |
dc.subject | Middle Aged | en_GB |
dc.subject | Oxocins | en_GB |
dc.subject | Recreation | en_GB |
dc.subject | Respiratory Function Tests | en_GB |
dc.title | Initial evaluation of the effects of aerosolized Florida red tide toxins (brevetoxins) in persons with asthma | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2018-01-02T11:51:30Z | |
dc.identifier.issn | 0091-6765 | |
exeter.place-of-publication | United States | en_GB |
dc.description | This is the final version of the article. Available from NIEHS via the DOI in this record. | en_GB |
dc.identifier.journal | Environmental Health Perspectives | en_GB |