Mechanisms and consequences of diversity-generating immune strategies
Nature Reviews Immunology
© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Reason for embargo
Under embargo until 7 February 2018 in compliance with publisher policy
Species from all five kingdoms of life have evolved sophisticated mechanisms to generate diversity in genes that are involved in host-pathogen interactions, conferring reduced levels of parasitism to both individuals and populations. Here, we highlight unifying concepts that underpin these evolutionarily unrelated diversity-generating mechanisms (DGMs). We discuss the mechanisms of and selective forces acting on these diversity-generating immune strategies, as well as their epidemiological and co-evolutionary consequences. We propose that DGMs can be broadly classified into two classes - targeted and untargeted DGMs - which generate different levels of diversity with important consequences for host-parasite co-evolution.
E.R.W. and A.B. acknowledge the Natural Environment Research Council, the Biotechnology and Biological Sciences Research Council, the Royal Society, the Leverhulme Trust, the Wellcome Trust, the European Research Council and the AXA research fund for funding.
This is the author accepted manuscript. The final version is available from Springer Nature via the DOI in this record.
Vol. 17, pp. 719 - 728
Place of publication