Unloosing the Gordian knot of peroxisome formation
Current Opinion in Cell Biology
Elsevier for Current Opinion
© 2018 The Authors. Published by Elsevier Ltd. Open access under a Creative Commons license: https://creativecommons.org/licenses/by/4.0/
Peroxisome biogenesis is governed by molecular machineries, which are either unique to peroxisomes or are partially shared with mitochondria. As peroxisomes have important protective functions in the cell, modulation of their number is important for human health and disease. Significant progress has been made towards our understanding of the mechanisms of peroxisome formation, revealing a remarkable plasticity of the peroxisome biogenesis pathway. Here we discuss most recent findings with particular focus on peroxisome formation in mammalian cells.
This work was supported by the Biotechnology and Biological Sciences Research Council (BB/K006231/1, BB/N01541X/1 to M.S.).
This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record
Vol. 50, pp. 50-56