dc.contributor.author | Galloway, T | |
dc.contributor.author | Baglin, N | |
dc.contributor.author | Lee, BP | |
dc.contributor.author | Kocur, AL | |
dc.contributor.author | Shepherd, M | |
dc.contributor.author | Steele, A | |
dc.contributor.author | BPA Schools Study Consortium | |
dc.contributor.author | Harries, LW | |
dc.date.accessioned | 2018-02-12T15:59:05Z | |
dc.date.issued | 2018-02-03 | |
dc.description.abstract | Objective Bisphenol A (BPA) has been associated with adverse human health outcomes and exposure to this compound is near-ubiquitous in the Western world. We aimed to examine whether self-moderation of BPA exposure is possible by altering diet in a real-world setting.
Design An Engaged Research dietary intervention study designed, implemented and analysed by healthy teenagers from six schools and undertaken in their own homes.
Participants A total of 94 students aged between 17 and 19 years from schools in the South West of the UK provided diet diaries and urine samples for analysis.
Intervention Researcher participants designed a set of literature-informed guidelines for the reduction of dietary BPA to be followed for 7 days.
Main outcome measures Creatinine-adjusted urinary BPA levels were taken before and after the intervention. Information on packaging and food/drink ingested was used to calculate a BPA risk score for anticipated exposure. A qualitative analysis was carried out to identify themes addressing long-term sustainability of the diet.
Results BPA was detected in urine of 86% of participants at baseline at a median value of 1.22 ng/mL (IQR 1.99). No effect of the intervention diet on BPA levels was identified overall (P=0.25), but there was a positive association in those participants who showed a drop in urinary BPA concentration postintervention and their initial BPA level (P=0.003). Qualitative analysis identified themes around feelings of lifestyle restriction and the inadequacy of current labelling practices.
Conclusions We found no evidence in this self-administered intervention study that it was possible to moderate BPA exposure by diet in a real-world setting. Furthermore, our study participants indicated that they would be unlikely to sustain such a diet long term, due to the difficulty in identifying BPA-free foods. | en_GB |
dc.description.sponsorship | This study was funded by a Wellcome Trust People Award to LWH and TSG (grant no 105162/Z/14/Z). TSG was additionally supported by NERC awards NE/L007010 and NE/N006178/1 | en_GB |
dc.identifier.citation | Vol. 8, article e018742 | en_GB |
dc.identifier.doi | 10.1136/bmjopen-2017-018742 | |
dc.identifier.uri | http://hdl.handle.net/10871/31428 | |
dc.language.iso | en | en_GB |
dc.publisher | BMJ Publishing Group | en_GB |
dc.relation.source | Data are available on reasonable request by emailing the corresponding author (L.W.Harries@exeter.ac.uk). | en_GB |
dc.rights | © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/ | en_GB |
dc.title | An engaged research study to assess the effect of a ‘real-world’ dietary intervention on urinary bisphenol A (BPA) levels in teenagers | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2018-02-12T15:59:05Z | |
dc.identifier.issn | 2044-6055 | |
dc.description | This is the final version of the article. Available from BMJ Publishing Group via the DOI in this record. | en_GB |
dc.identifier.journal | BMJ Open | en_GB |