Variable-Internal-Stores models of microbial growth and metabolism with dynamic allocation of cellular resources.
van den Berg, HA
Journal of Mathematical Biology
© The Author(s) 2016 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Variable-Internal-Stores models of microbial metabolism and growth have proven to be invaluable in accounting for changes in cellular composition as microbial cells adapt to varying conditions of nutrient availability. Here, such a model is extended with explicit allocation of molecular building blocks among various types of catalytic machinery. Such an extension allows a reconstruction of the regulatory rules employed by the cell as it adapts its physiology to changing environmental conditions. Moreover, the extension proposed here creates a link between classic models of microbial growth and analyses based on detailed transcriptomics and proteomics data sets. We ascertain the compatibility between the extended Variable-Internal-Stores model and the classic models, demonstrate its behaviour by means of simulations, and provide a detailed treatment of the uniqueness and the stability of its equilibrium point as a function of the availabilities of the various nutrients.
OAN was funded through EU Research Framework programme 7 Marie Curie Actions, grant 316630 Centre for Analytical Science – Innovative Doctoral Programme (CAS-IDP).
This is the final version of the article. Available from Springer via the DOI in this record. An erratum to this article is available at http://dx.doi.org/10.1007/s00285-016-1044-y
Vol. 74 (1-2), pp. 409 - 445
Place of publication