Mathematical models of microbial growth and metabolism: A whole-organism perspective
van Den Berg, HA
Science Reviews 2000
© 2017, Science Reviews 2000 Ltd. All rights reserved.
We review the principles underpinning the development of mathematical models of the metabolic activities of micro-organisms. Such models are important to understand and chart the substantial contributions made by micro-organisms to geochemical cycles, and also to optimise the performance of bioreactors that exploit the biochemical capabilities of these organisms. We advocate an approach based on the principle of dynamic allocation. We survey the biological background that motivates this approach, including nutrient assimilation, the regulation of gene expression, and the principles of microbial growth. In addition, we discuss the classic models of microbial growth as well as contemporary approaches. The dynamic allocation theory generalises these classic models in a natural manner and is readily amenable to the additional information provided by transcriptomics and proteomics approaches. Finally, we touch upon these organising principles in the context of the transition from the free-living unicellular mode of life to multicellularity.
Olga Nev was funded through EU Research Framework programme 7 Marie Curie Actions, grant 316630 Centre for Analytical Science – Innovative Doctoral Programme (CAS-IDP).
This is the author accepted manuscript. The final version is available from Science Reviews 2000 via the DOI in this record.
Vol. 100 (4), pp. 343 - 362