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dc.contributor.authorBlanco, W
dc.contributor.authorBertram, R
dc.contributor.authorTabak, J
dc.date.accessioned2018-02-22T08:36:19Z
dc.date.issued2017
dc.description.abstractEarly in development, neural systems have primarily excitatory coupling, where even GABAergic synapses are excitatory. Many of these systems exhibit spontaneous episodes of activity that have been characterized through both experimental and computational studies. As development progress the neural system goes through many changes, including synaptic remodeling, intrinsic plasticity in the ion channel expression, and a transformation of GABAergic synapses from excitatory to inhibitory. What effect each of these, and other, changes have on the network behavior is hard to know from experimental studies since they all happen in parallel. One advantage of a computational approach is that one has the ability to study developmental changes in isolation. Here, we examine the effects of GABAergic synapse polarity change on the spontaneous activity of both a mean field and a neural network model that has both glutamatergic and GABAergic coupling, representative of a developing neural network. We find some intuitive behavioral changes as the GABAergic neurons go from excitatory to inhibitory, shared by both models, such as a decrease in the duration of episodes. We also find some paradoxical changes in the activity that are only present in the neural network model. In particular, we find that during early development the inter-episode durations become longer on average, while later in development they become shorter. In addressing this unexpected finding, we uncover a priming effect that is particularly important for a small subset of neurons, called the "intermediate neurons." We characterize these neurons and demonstrate why they are crucial to episode initiation, and why the paradoxical behavioral change result from priming of these neurons. The study illustrates how even arguably the simplest of developmental changes that occurs in neural systems can present non-intuitive behaviors. It also makes predictions about neural network behavioral changes that occur during development that may be observable even in actual neural systems where these changes are convoluted with changes in synaptic connectivity and intrinsic neural plasticity.en_GB
dc.description.sponsorshipWB was supported by a scholarship (Process #202320/2015-4) from the Brazilian National Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Cientifico e Tecnológico—CNPq). RB was partially supported by National Science Foundation granten_GB
dc.identifier.citationVol 11: article 88en_GB
dc.identifier.doi10.3389/fncom.2017.00088
dc.identifier.urihttp://hdl.handle.net/10871/31616
dc.language.isoenen_GB
dc.publisherFrontiers Mediaen_GB
dc.relation.sourceThe Supplementary Material for this article can be found online at: http://journal.frontiersin.org/article/10.3389/fncom. 2017.00088/full#supplementary-materialen_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/29085291en_GB
dc.subjectGABAergic neuronsen_GB
dc.subjectactivity episodesen_GB
dc.subjectdeveloping neural networksen_GB
dc.subjectexcitatory-inhibitory balanceen_GB
dc.subjectheterogeneityen_GB
dc.titleThe effects of GABAergic polarity changes on episodic neural network activity in developing neural systemsen_GB
dc.typeArticleen_GB
dc.date.available2018-02-22T08:36:19Z
dc.identifier.issn1662-5188
exeter.place-of-publicationSwitzerlanden_GB
dc.descriptionThis is the final version of the article. Available from the publisher via the DOI in this record.en_GB
dc.identifier.journalFrontiers in Computational Neuroscienceen_GB


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