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dc.contributor.authorMiquel, S
dc.contributor.authorChamp, C
dc.contributor.authorDay, J
dc.contributor.authorAarts, E
dc.contributor.authorBahr, BA
dc.contributor.authorBakker, M
dc.contributor.authorBánáti, D
dc.contributor.authorCalabrese, V
dc.contributor.authorCederholm, T
dc.contributor.authorCryan, J
dc.contributor.authorDye, L
dc.contributor.authorFarrimond, JA
dc.contributor.authorKorosi, A
dc.contributor.authorLayé, S
dc.contributor.authorMaudsley, S
dc.contributor.authorMilenkovic, D
dc.contributor.authorMohajeri, MH
dc.contributor.authorSijben, J
dc.contributor.authorSolomon, A
dc.contributor.authorSpencer, JPE
dc.contributor.authorThuret, S
dc.contributor.authorVanden Berghe, W
dc.contributor.authorVauzour, D
dc.contributor.authorVellas, B
dc.contributor.authorWesnes, K
dc.contributor.authorWillatts, P
dc.contributor.authorWittenberg, R
dc.contributor.authorGeurts, L
dc.date.accessioned2018-02-26T09:31:32Z
dc.date.issued2017-12-15
dc.description.abstractBACKGROUND: Ageing is a highly complex process marked by a temporal cascade of events, which promote alterations in the normal functioning of an individual organism. The triggers of normal brain ageing are not well understood, even less so the factors which initiate and steer the neuronal degeneration, which underpin disorders such as dementia. A wealth of data on how nutrients and diets may support cognitive function and preserve brain health are available, yet the molecular mechanisms underlying their biological action in both normal ageing, age-related cognitive decline, and in the development of neurodegenerative disorders have not been clearly elucidated. OBJECTIVES: This review aims to summarise the current state of knowledge of vulnerabilities that predispose towards dysfunctional brain ageing, highlight potential protective mechanisms, and discuss dietary interventions that may be used as therapies. A special focus of this paper is on the impact of nutrition on neuroprotection and the underlying molecular mechanisms, and this focus reflects the discussions held during the 2nd workshop 'Nutrition for the Ageing Brain: Functional Aspects and Mechanisms' in Copenhagen in June 2016. The present review is the most recent in a series produced by the Nutrition and Mental Performance Task Force under the auspice of the International Life Sciences Institute Europe (ILSI Europe). CONCLUSION: Coupling studies of cognitive ageing with studies investigating the effect of nutrition and dietary interventions as strategies targeting specific mechanisms, such as neurogenesis, protein clearance, inflammation, and non-coding and microRNAs is of high value. Future research on the impact of nutrition on cognitive ageing will need to adopt a longitudinal approach and multimodal nutritional interventions will likely need to be imposed in early-life to observe significant impact in older age.en_GB
dc.description.sponsorshipThe workshop ‘Nutrition for the Ageing Brain: Functional Aspects and Strategies’ was organized with funds from the ILSI Europe Nutrition and Mental Performance Task Force.en_GB
dc.identifier.citationVol. 42, pp. 40 - 55en_GB
dc.identifier.doi10.1016/j.arr.2017.12.004
dc.identifier.otherS1568-1637(17)30206-4
dc.identifier.urihttp://hdl.handle.net/10871/31668
dc.language.isoenen_GB
dc.publisherElsevier Massonen_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/29248758en_GB
dc.rights© 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).en_GB
dc.subjectCognitionen_GB
dc.subjectCognitive declineen_GB
dc.subjectNeuro-inflammationen_GB
dc.subjectNeuroprotectionen_GB
dc.subjectPlant-food bioactivesen_GB
dc.subjectPreventive dieten_GB
dc.titlePoor cognitive ageing: Vulnerabilities, mechanisms and the impact of nutritional interventions.en_GB
dc.typeArticleen_GB
dc.date.available2018-02-26T09:31:32Z
dc.identifier.issn1568-1637
exeter.place-of-publicationEnglanden_GB
dc.descriptionThis is the final version of the article. Available from Elsevier Masson via the DOI in this record.en_GB
dc.identifier.journalAgeing Research Reviewsen_GB


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