Elevated polygenic burden for autism is associated with differential DNA methylation at birth
Hannon, E; Schendel, D; Ladd-Acosta, C; et al.Grove, J; Hansen, CS; Andrews, SV; Hougaard, DM; Bresnahan, M; Mors, O; Hollegaard, MV; Bækvad-Hansen, M; Hornig, M; Mortensen, PB; Børglum, AD; Werge, T; Pedersen, MG; Nordentoft, M; Buxbaum, J; Daniele Fallin, M; Bybjerg-Grauholm, J; Reichenberg, A; Mill, J
Date: 28 March 2018
Journal
Genome Medicine
Publisher
BioMed Central
Publisher DOI
Abstract
Autism spectrum disorder (ASD) is a severe neurodevelopmental disorder characterized by deficits in social communication and restricted, repetitive behaviors, interests, or activities. The etiology of ASD involves both inherited and environmental risk factors, with epigenetic processes hypothesized as one mechanism by which both genetic ...
Autism spectrum disorder (ASD) is a severe neurodevelopmental disorder characterized by deficits in social communication and restricted, repetitive behaviors, interests, or activities. The etiology of ASD involves both inherited and environmental risk factors, with epigenetic processes hypothesized as one mechanism by which both genetic and non-genetic variation influence gene regulation and pathogenesis. The aim of this study was to identify DNA methylation biomarkers of ASD detectable at birth.
Institute of Biomedical & Clinical Science
Collections of Former Colleges
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