dc.contributor.author | Randel, N | |
dc.contributor.author | Asadulina, A | |
dc.contributor.author | Bezares-Calderón, LA | |
dc.contributor.author | Verasztó, C | |
dc.contributor.author | Williams, EA | |
dc.contributor.author | Conzelmann, M | |
dc.contributor.author | Shahidi, R | |
dc.contributor.author | Jékely, G | |
dc.date.accessioned | 2018-05-14T12:10:09Z | |
dc.date.issued | 2014-05-27 | |
dc.description.abstract | Animals use spatial differences in environmental light levels for visual navigation; however, how light inputs are translated into coordinated motor outputs remains poorly understood. Here we reconstruct the neuronal connectome of a four-eye visual circuit in the larva of the annelid Platynereis using serial-section transmission electron microscopy. In this 71-neuron circuit, photoreceptors connect via three layers of interneurons to motorneurons, which innervate trunk muscles. By combining eye ablations with behavioral experiments, we show that the circuit compares light on either side of the body and stimulates body bending upon left-right light imbalance during visual phototaxis. We also identified an interneuron motif that enhances sensitivity to different light intensity contrasts. The Platynereis eye circuit has the hallmarks of a visual system, including spatial light detection and contrast modulation, illustrating how image-forming eyes may have evolved via intermediate stages contrasting only a light and a dark field during a simple visual task. | en_GB |
dc.description.sponsorship | The research leading to these results received
funding from the European Research Council under the European Union's Seventh Framework
Programme (FP7/2007-2013)/European Research Council Grant Agreement 260821. | en_GB |
dc.identifier.citation | Vol. 3: e02730 | en_GB |
dc.identifier.doi | 10.7554/eLife.02730 | |
dc.identifier.uri | http://hdl.handle.net/10871/32832 | |
dc.language.iso | en | en_GB |
dc.publisher | eLife Sciences Publications | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/24867217 | en_GB |
dc.rights | Copyright Randel et al. This
article is distributed under the
terms of the Creative Commons
Attribution License, which
permits unrestricted use and
redistribution provided that the
original author and source are
credited. | en_GB |
dc.subject | Platynereis | en_GB |
dc.subject | annelid | en_GB |
dc.subject | connectomics | en_GB |
dc.subject | eye evolution | en_GB |
dc.subject | neuroscience | en_GB |
dc.subject | phototaxis | en_GB |
dc.subject | platynereis dumerilii | en_GB |
dc.subject | Amino Acid Motifs | en_GB |
dc.subject | Animals | en_GB |
dc.subject | Annelida | en_GB |
dc.subject | Behavior, Animal | en_GB |
dc.subject | Connectome | en_GB |
dc.subject | Gene Expression Profiling | en_GB |
dc.subject | In Situ Hybridization | en_GB |
dc.subject | Interneurons | en_GB |
dc.subject | Light | en_GB |
dc.subject | Microscopy, Electron, Transmission | en_GB |
dc.subject | Models, Neurological | en_GB |
dc.subject | Neurons | en_GB |
dc.subject | Neurotransmitter Agents | en_GB |
dc.subject | Photoreceptor Cells, Invertebrate | en_GB |
dc.subject | Synapses | en_GB |
dc.subject | Vision, Ocular | en_GB |
dc.title | Neuronal connectome of a sensory-motor circuit for visual navigation. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2018-05-14T12:10:09Z | |
exeter.place-of-publication | England | en_GB |
dc.description | This is the final version of the article. Available from eLife Sciences Publications via the DOI in this record. | en_GB |
dc.identifier.eissn | 2050-084X | |
dc.identifier.journal | eLife | en_GB |