dc.contributor.author | Randel, N | |
dc.contributor.author | Shahidi, R | |
dc.contributor.author | Verasztó, C | |
dc.contributor.author | Bezares-Calderón, LA | |
dc.contributor.author | Schmidt, S | |
dc.contributor.author | Jékely, G | |
dc.date.accessioned | 2018-05-14T13:56:56Z | |
dc.date.issued | 2015-06-10 | |
dc.description.abstract | Developmental programs have the fidelity to form neural circuits with the same structure and function among individuals of the same species. It is less well understood, however, to what extent entire neural circuits of different individuals are similar. Previously, we reported the neuronal connectome of the visual eye circuit from the head of a Platynereis dumerilii larva (Randel et al., 2014). We now report a full-body serial section transmission electron microscopy (ssTEM) dataset of another larva of the same age, for which we describe the connectome of the visual eyes and the larval eyespots. Anatomical comparisons and quantitative analyses of the two circuits reveal a high inter-individual stereotypy of the cell complement, neuronal projections, and synaptic connectivity, including the left-right asymmetry in the connectivity of some neurons. Our work shows the extent to which the eye circuitry in Platynereis larvae is hard-wired. | en_GB |
dc.description.sponsorship | The research leading to these
results received funding from the European Research Council under the European Union’s Seventh
Framework Programme (FP7/2007–2013)/European Research Council Grant Agreement 260821. | en_GB |
dc.description.sponsorship | European Research Council (ERC): Grant Agreement 260821, Gaspar Jekely | en_GB |
dc.identifier.citation | Vol. 4: e08069 | en_GB |
dc.identifier.doi | 10.7554/eLife.08069 | |
dc.identifier.uri | http://hdl.handle.net/10871/32846 | |
dc.language.iso | en | en_GB |
dc.publisher | eLife Sciences Publications | en_GB |
dc.relation.source | Source code 1. Blender file containing the visual eye and larval eyespot connectome reconstructed
from HT9-4. The file contains the complete anatomical model and connectivity information of the
reconstructed visual eye and eyespot circuit from the whole-body dataset of HT9-4. Blender can be
downloaded from [http://www.blender.org/]. Display settings can be changed and the connectivity
can be analyzed as described in (Asadulina et al., 2015).
DOI: 10.7554/eLife.08069.014 | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/26061864 | en_GB |
dc.rights | Copyright Randel et al. This
article is distributed under the
terms of the Creative Commons
Attribution License, which
permits unrestricted use and
redistribution provided that the
original author and source are
credited | en_GB |
dc.subject | Platynereis dumerilii | en_GB |
dc.subject | connectome | en_GB |
dc.subject | neural circuit | en_GB |
dc.subject | neuroscience | en_GB |
dc.subject | stereotypy | en_GB |
dc.subject | Animals | en_GB |
dc.subject | Connectome | en_GB |
dc.subject | Larva | en_GB |
dc.subject | Microscopy, Electron, Transmission | en_GB |
dc.subject | Microtomy | en_GB |
dc.subject | Polychaeta | en_GB |
dc.subject | Vision, Ocular | en_GB |
dc.subject | Visual Perception | en_GB |
dc.title | Inter-individual stereotypy of the Platynereis larval visual connectome | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2018-05-14T13:56:56Z | |
exeter.place-of-publication | England | en_GB |
dc.description | This is the final version of the article. Available from the publisher via the DOI in this record. | en_GB |
dc.identifier.eissn | 2050-084X | |
dc.identifier.journal | eLife | en_GB |