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dc.contributor.authorAtkins, JL
dc.contributor.authorDelgado, J
dc.contributor.authorPilling, L
dc.contributor.authorBowman, K
dc.contributor.authorMasoli, J
dc.contributor.authorKuchel, G
dc.contributor.authorFerrucci, L
dc.contributor.authorMelzer, D
dc.date.accessioned2018-05-23T14:45:03Z
dc.date.issued2018-05-21
dc.description.abstractBackground Individuals with low cardiovascular risk factor profiles experience lower rates of cardiovascular diseases, but associations with geriatric syndromes are unclear. We tested whether individuals with low cardiovascular disease risk, aged 60–69 years old at baseline in two large cohorts, were less likely to develop aging-related adverse health outcomes. Methods Data were from population representative medical records (Clinical Practice Research Datalink [CPRD] England, n = 239,591) and healthy volunteers (UK Biobank [UKB], n = 181,820), followed for ≤10 years. A cardiovascular disease risk score (CRS) summarized smoking status, LDL-cholesterol, blood pressure, body mass index, fasting glucose and physical activity, grouping individuals as low (ie, all factors near ideal), moderate, or high CRS. Logistic regression, Cox models, and Fine and Grey risk models tested the associations between the CRS and health outcomes. Results Low CRS individuals had less chronic pain (UKB: baseline odds ratio = 0.52, confidence interval [CI] = 0.50–0.54), lower incidence of incontinence (CPRD: subhazard ratio [sub-HR] = 0.75, 0.63–0.91), falls (sub-HR = 0.82, CI = 0.73–0.91), fragility fractures (sub-HR = 0.78, CI = 0.65–0.93), and dementia (vs. high risks; UKB: sub-HR = 0.67, CI = 0.50–0.89; CPRD: sub-HR = 0.79, CI = 0.56–1.12). Only 5.4% in CPRD with low CRS became frail (Rockwood index) versus 24.2% with high CRS. All-cause mortality was markedly lower in the low CRS group (vs. high CRS; HR = 0.40, 95% CI = 0.35–0.47). All associations showed dose–response relationships, and results were similar in both cohorts. Conclusions Persons aged 60–69 years with near-ideal cardiovascular risk factor profiles have substantially lower incidence of geriatric conditions and frailty. Optimizing cardiovascular disease risk factors may substantially reduce the burden of morbidity in later life.en_GB
dc.description.sponsorshipThis work was mainly supported by the UK Medical Research Council (grant number MR/M023095/1) and the National Institute for Health Research (NIHR) School for Public Health Research (SPHR) Ageing Well Program. Supported in part by the Intramural Research Program of the National Institute of Aging, NIH, Baltimore, MDen_GB
dc.identifier.citationPublished online 21 May 2018en_GB
dc.identifier.doi10.1093/gerona/gly083
dc.identifier.urihttp://hdl.handle.net/10871/32972
dc.language.isoenen_GB
dc.publisherOxford University Press (OUP) for Gerontological Society of Americaen_GB
dc.rights© The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.en_GB
dc.subjectCardiovascular risken_GB
dc.subjectHealthy agingen_GB
dc.subjectFrailtyen_GB
dc.subjectIncontinenceen_GB
dc.subjectChronic painen_GB
dc.titleImpact of Low Cardiovascular Risk Profiles on Geriatric Outcomes: Evidence From 421,000 Participants in Two Cohortsen_GB
dc.typeArticleen_GB
dc.date.available2018-05-23T14:45:03Z
dc.descriptionThis is the final version of the article. Available from OUP via the DOI in this record.en_GB
dc.identifier.journalJournals of Gerontology: Series Aen_GB


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