Show simple item record

WNK kinase signaling in ion homeostasis and human disease

dc.contributor.authorShekarabi, M
dc.contributor.authorZhang, J
dc.contributor.authorKhanna, AR
dc.contributor.authorEllison, DH
dc.contributor.authorDelpire, E
dc.contributor.authorKahle, KT
dc.date.accessioned2018-07-06T14:10:00Z
dc.date.issued2017-02-07
dc.description.abstractWNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl- cotransporters [CCCs]), comprise a signaling cascade essential for ion homeostasis in the kidney and nervous system. Recent work has furthered our understanding of the WNKs in epithelial transport, cell volume homeostasis, and GABA signaling, and uncovered novel roles for this pathway in immune cell function and cell proliferation.en_GB
dc.description.sponsorshipThis work was supported by a NIHNRCDP grant (K.T.K.), Simons Foundation grant #400947 (K.T.K.), March of Dimes Basil O’Connor Award (K.T.K.), and NIH grant DK93501 to E.D.en_GB
dc.identifier.citationVol. 25 (2), pp. 285-299.en_GB
dc.identifier.doi10.1016/j.cmet.2017.01.007
dc.identifier.urihttp://hdl.handle.net/10871/33390
dc.language.isoenen_GB
dc.publisherElsevieren_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/28178566en_GB
dc.rights© 2017 Elsevier Inc.en_GB
dc.subjectGABAen_GB
dc.subjectKCC2en_GB
dc.subjectKCC3en_GB
dc.subjectNCCen_GB
dc.subjectNKCC1en_GB
dc.subjectWNK1en_GB
dc.subjectWNK3en_GB
dc.subjectWNK4en_GB
dc.subjectchlorideen_GB
dc.subjecthomeostasisen_GB
dc.subjectkidneyen_GB
dc.subjectAmino Acid Sequenceen_GB
dc.subjectAnimalsen_GB
dc.subjectBiological Transporten_GB
dc.subjectCell Sizeen_GB
dc.subjectDiseaseen_GB
dc.subjectHomeostasisen_GB
dc.subjectHumansen_GB
dc.subjectIonsen_GB
dc.subjectProtein-Serine-Threonine Kinasesen_GB
dc.subjectSignal Transductionen_GB
dc.titleWNK kinase signaling in ion homeostasis and human diseaseen_GB
dc.typeArticleen_GB
dc.date.available2018-07-06T14:10:00Z
dc.identifier.issn1550-4131
exeter.place-of-publicationUnited Statesen_GB
dc.descriptionThis is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.en_GB
dc.identifier.journalCell Metabolismen_GB


Files in this item

Name:
Accepted manuscript.pdf
Size:
1.093Mb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record