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dc.contributor.authorShimizu, K
dc.contributor.authorIijima, M
dc.contributor.authorSetiamarga, DH
dc.contributor.authorSarashina, I
dc.contributor.authorKudoh, T
dc.contributor.authorAsami, T
dc.contributor.authorGittenberger, E
dc.contributor.authorEndo, K
dc.date.accessioned2018-09-24T10:01:11Z
dc.date.issued2013-05-28
dc.description.abstractBACKGROUND: Various shapes of gastropod shells have evolved ever since the Cambrian. Although theoretical analyses of morphogenesis exist, the molecular basis of shell development remains unclear. We compared expression patterns of the decapentaplegic (dpp) gene in the shell gland and mantle tissues at various developmental stages between coiled-shell and non-coiled-shell gastropods. RESULTS: We analyzed the expression patterns of dpp for the two limpets Patella vulgata and Nipponacmea fuscoviridis, and for the dextral wild-type and sinistral mutant lineage of the pond snail Lymnaea stagnalis. The limpets had symmetric expression patterns of dpp throughout ontogeny, whereas in the pond snail, the results indicated asymmetric and mirror image patterns between the dextral and sinistral lineages. CONCLUSION: We hypothesize that Dpp induces mantle expansion, and the presence of a left/right asymmetric gradient of the Dpp protein causes the formation of a coiled shell. Our results provide a molecular explanation for shell, coiling including new insights into expression patterns in post-embryonic development, which should aid in understanding how various shell shapes are formed and have evolved in the gastropods.en_GB
dc.description.sponsorshipThis study was supported by the JSPS Grants-in-Aid for Scientific Research 15104009.en_GB
dc.identifier.citationVol. 4, article 15en_GB
dc.identifier.doi10.1186/2041-9139-4-15
dc.identifier.urihttp://hdl.handle.net/10871/34086
dc.language.isoenen_GB
dc.publisherBMC (part of Springer Nature)en_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/23711320en_GB
dc.rights© Shimizu et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_GB
dc.subjectLeft-right asymmetryen_GB
dc.subjectDecapentaplegicen_GB
dc.subjectShell coilingen_GB
dc.subjectGastropodsen_GB
dc.titleLeft-right asymmetric expression of dpp in the mantle of gastropods correlates with asymmetric shell coilingen_GB
dc.typeArticleen_GB
dc.date.available2018-09-24T10:01:11Z
dc.identifier.issn2041-9139
exeter.place-of-publicationEnglanden_GB
dc.descriptionThis is the final version of the article. Available from BMC via the DOI in this record.en_GB
dc.identifier.journalEvoDevoen_GB


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