dc.contributor.author | Smalla, K | |
dc.contributor.author | Cook, K | |
dc.contributor.author | Djordjevic, SP | |
dc.contributor.author | Klumper, U | |
dc.contributor.author | Gillings, M | |
dc.date.accessioned | 2018-10-02T10:16:49Z | |
dc.date.issued | 2018-10-02 | |
dc.description.abstract | Antibiotic resistance is one of the major problems facing medical practice in the 21st century. Historical approaches to managing antibiotic resistance have often focused on individual patients, specific pathogens, and particular resistance phenotypes. However, it is increasingly recognized that antibiotic resistance is a complex ecological and evolutionary problem. As such, understanding the dynamics of antibiotic resistance requires integration of data on the diverse mobile genetic elements often associated to antibiotic resistance genes, and their dissemination through various mechanisms of horizontal gene transfer between bacterial cells and environments. Most important is understanding of the fate and effects of antibiotics at sub-inhibitory concentration and co-selection. This opinion paper identifies key knowledge gaps in our understanding of resistance phenomena, and outlines research needs that should be addressed to help us manage resistance into the future. | en_GB |
dc.identifier.citation | Published online 2 October 2018 | en_GB |
dc.identifier.doi | 10.1093/femsec/fiy195 | |
dc.identifier.uri | http://hdl.handle.net/10871/34172 | |
dc.language.iso | en | en_GB |
dc.publisher | Oxford University Press (OUP) for Federation of European Microbiological Societies | en_GB |
dc.rights.embargoreason | Under embargo until 2 October 2019 in compliance with publisher policy | en_GB |
dc.rights | © FEMS 2018 | en_GB |
dc.subject | plasmid | en_GB |
dc.subject | insertion element | en_GB |
dc.subject | microbiome | en_GB |
dc.subject | One Health | en_GB |
dc.subject | evolution | en_GB |
dc.subject | pathogen | en_GB |
dc.title | Environmental dimensions of antibiotic resistance: Assessment of basic science gaps | en_GB |
dc.type | Article | en_GB |
dc.identifier.issn | 0168-6496 | |
dc.description | This is the author accepted manuscript. The final version is available from OUP via the DOI in this record | en_GB |
dc.identifier.journal | FEMS Microbiology Ecology | en_GB |