dc.contributor.author | Roberts, KE | |
dc.contributor.author | Hadfield, JD | |
dc.contributor.author | Sharma, MD | |
dc.contributor.author | Longdon, B | |
dc.date.accessioned | 2018-10-16T12:56:49Z | |
dc.date.issued | 2018-10-19 | |
dc.description.abstract | Host shifts – where a pathogen jumps between different host species – are an important source of emerging infectious disease. With on-going climate change there is an increasing need to understand the effect changes in temperature may have on emerging infectious disease. We investigated whether species’ susceptibilities change with temperature and ask if susceptibility is greatest at different temperatures in different species. We infected 45 species of Drosophilidae with an RNA virus and measured how viral load changes with temperature. We found the host phylogeny explained a large proportion of the variation in viral load at each temperature, with strong phylogenetic correlations between viral loads
across temperature. The variance in viral load increased with temperature, while the mean viral load did not. This suggests that as temperature increases the most susceptible species become more susceptible, and the least susceptible less so. We found no significant relationship between a species’ susceptibility across temperatures, and proxies for thermal optima (critical thermal maximum and minimum or basal metabolic rate). These results suggest that whilst the rank order of species susceptibilities may remain the same with changes in temperature, some species may become more susceptible to a novel pathogen, and others less so. | en_GB |
dc.identifier.citation | Vol. 14 (10). Published online 19 October 2018. | en_GB |
dc.identifier.doi | 10.1371/journal.ppat.1007185 | |
dc.identifier.uri | http://hdl.handle.net/10871/34316 | |
dc.language.iso | en | en_GB |
dc.publisher | Public Library of Science (PLoS) | en_GB |
dc.relation.url | https://figshare.com/account/home#/projects/30692 | en_GB |
dc.rights | © 2018 Roberts et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
dc.title | Changes in temperature alter the potential outcomes of virus host shifts | en_GB |
dc.type | Article | en_GB |
dc.identifier.issn | 1553-7366 | |
dc.description | This is the author accepted manuscript. The final version is available from Public Library of Science via the DOI in this record. | en_GB |
dc.description | Full project dataset: https://figshare.com/account/home#/projects/30692 | en_GB |
dc.identifier.journal | PLoS Pathogens | en_GB |