dc.contributor.author | Pilling, LC | |
dc.contributor.author | Kuo, C-L | |
dc.contributor.author | Sicinski, K | |
dc.contributor.author | Tamosauskaite, J | |
dc.contributor.author | Kuchel, GA | |
dc.contributor.author | Harries, LW | |
dc.contributor.author | Herd, P | |
dc.contributor.author | Wallace, R | |
dc.contributor.author | Ferrucci, L | |
dc.contributor.author | Melzer, D | |
dc.date.accessioned | 2018-10-19T10:37:29Z | |
dc.date.issued | 2017-12-06 | |
dc.description.abstract | We undertook a genome-wide association study (GWAS) of parental longevity in European descent UK Biobank participants. For combined mothers' and fathers' attained age, 10 loci were associated (p<5*10-8), including 8 previously identified for traits including survival, Alzheimer's and cardiovascular disease. Of these, 4 were also associated with longest 10% survival (mothers age ≥90 years, fathers ≥87 years), with 2 additional associations including MC2R intronic variants (coding for the adrenocorticotropic hormone receptor). Mother's age at death was associated with 3 additional loci (2 linked to autoimmune conditions), and 8 for fathers only. An attained age genetic risk score associated with parental survival in the US Health and Retirement Study and the Wisconsin Longitudinal Study and with having a centenarian parent (n=1,181) in UK Biobank. The results suggest that human longevity is highly polygenic with prominent roles for loci likely involved in cellular senescence and inflammation, plus lipid metabolism and cardiovascular conditions. There may also be gender specific routes to longevity. | en_GB |
dc.description.sponsorship | This work was generously funded by an award to DM and LH by the Medical Research Council MR/M023095/1. LF is supported by the Intramural Research Program of the National Institute on Aging, U.S. National Institutes of Health. Input from CK and GK was supported by the University of Connecticut Health Center. The Health and Retirement Study (HRS) is a longitudinal project sponsored by the National Institute on Aging (NIA U01AG009740) and the Social Security Administration. This research uses data from the Wisconsin Longitudinal Study (WLS) of the University of Wisconsin-Madison. Since 1991, the WLS has been supported principally by the National Institute on Aging (AG09775, AG21079 and AG33285), with additional support from the Vilas Estate Trust, the National Science Foundation, the Spencer Foundation and the Graduate School of the University of Wisconsin-Madison. | en_GB |
dc.identifier.citation | Vol. 9 (12), pp. 2504 - 2520 | en_GB |
dc.identifier.doi | 10.18632/aging.101334 | |
dc.identifier.uri | http://hdl.handle.net/10871/34358 | |
dc.language.iso | en | en_GB |
dc.publisher | Impact Journals | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/29227965 | en_GB |
dc.rights | © 2017 Pilling et al. This is an open‐access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_GB |
dc.subject | 1417 | en_GB |
dc.subject | GWAS | en_GB |
dc.subject | genetic | en_GB |
dc.subject | human | en_GB |
dc.subject | longevity | en_GB |
dc.title | Human longevity: 25 genetic loci associated in 389,166 UK biobank participants | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2018-10-19T10:37:29Z | |
exeter.place-of-publication | United States | en_GB |
dc.description | This is the final version. Freely available on open access from Impact Journals via the DOI in this record | en_GB |
dc.description | A public use file of data from the WLS is available from the Wisconsin Longitudinal Study, University of Wisconsin-Madison, 1180 Observatory Drive, Madison, Wisconsin 53706 and at (http://www.ssc.wisc.edu/wlsresearch/data). | en_GB |
dc.identifier.journal | Aging | en_GB |