dc.contributor.author | Archer, R | |
dc.contributor.author | Recker, M | |
dc.contributor.author | Duffy, E | |
dc.contributor.author | Hosken, D | |
dc.date.accessioned | 2018-11-09T15:50:55Z | |
dc.date.issued | 2018-11-28 | |
dc.description.abstract | At any given age, men are more likely to die than women, but women have poorer health at
older ages. This is referred to as the “male-female, health-survival paradox”, which is not
fully understood. Here, we provide a general solution to the paradox that relies on intralocus
sexual conflict, where alleles segregating in the population have late-acting positive effects
on male fitness, but negative effects on female health. Using an evolutionary modelling
framework we show that male-benefit, female-detriment alleles can spread if they are
expressed after female reproduction stops. We provide support for our conflict based
solution using experimental Drosophila data. Our results show that selecting for increased
late-life male reproductive effort can increase male fitness but have a detrimental effect on
female fitness. Furthermore, we show that late-life male fertility is negatively genetically
correlated with female health. Our study suggests that intralocus sexual conflict could
resolve the health-survival paradox | en_GB |
dc.description.sponsorship | We thank the National Science Center
(Poland: 2013/09/N/NZ/NZ8/03231) and the Leverhulme Trust (UK: RF-2015-01) for funding
which partially supported this work, and the University of Exeter’s Dean’s Fellowship for
additional support. | en_GB |
dc.identifier.citation | Vol. 9, article 5048 | en_GB |
dc.identifier.doi | 10.1038/s41467-018-07541-y | |
dc.identifier.uri | http://hdl.handle.net/10871/34695 | |
dc.language.iso | en | en_GB |
dc.publisher | Springer Nature | en_GB |
dc.rights | © 2018 The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Intralocus sexual conflict can resolve the male-female health-survival paradox | en_GB |
dc.type | Article | en_GB |
dc.identifier.issn | 2041-1723 | |
dc.description | This is the final version. Available on open access from Springer Nature via the DOI in this record | en_GB |
dc.identifier.journal | Nature Communications | en_GB |
rioxxterms.licenseref.uri | http://creativecommons.org/licenses/by/4.0/ | |
refterms.dateFOA | 2018-12-17T14:27:55Z | |