dc.contributor.author | Allegra, E | |
dc.contributor.author | Titball, RW | |
dc.contributor.author | Carter, J | |
dc.contributor.author | Champion, OL | |
dc.date.accessioned | 2018-11-12T15:38:49Z | |
dc.date.issued | 2018-02-06 | |
dc.description.abstract | The acute toxicities of 19 chemicals were assessed using G. mellonella larvae. The results obtained were compared against LD50 values derived from in vitro cytotoxicity tests and against in vivo acute oral LD50 values. In general, cell culture systems overestimated the toxicity of chemicals, especially low toxicity chemicals. In contrast, toxicity testing in G. mellonella larvae was found to be a reliable predictor for low toxicity chemicals. For the 9 chemicals tested which were assigned to Globally Harmonised System (GHS) category 5, the toxicity measured in G. mellonella larvae was consistent with their GHS categorisation but cytotoxicity measured in 3T3 or NHK cells predicted 4 out of 9 chemicals as having low toxicity. A more robust assessment of the likely toxicity of chemicals in mammals could be made by taking into account their toxicities in both cell cultures and in G. mellonella larvae. | en_GB |
dc.description.sponsorship | This work was supported by the UK National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) award NC/S01604/1. | en_GB |
dc.identifier.citation | Vol. 198, pp. 469 - 472 | en_GB |
dc.identifier.doi | 10.1016/j.chemosphere.2018.01.175 | |
dc.identifier.uri | http://hdl.handle.net/10871/34734 | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/29425947 | en_GB |
dc.rights | © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) | en_GB |
dc.subject | Cell culture | en_GB |
dc.subject | Galleria mellonella | en_GB |
dc.subject | Globally Harmonised system | en_GB |
dc.subject | Toxicity testing | en_GB |
dc.subject | Animals | en_GB |
dc.subject | Cell Line | en_GB |
dc.subject | Larva | en_GB |
dc.subject | Mice | en_GB |
dc.subject | Moths | en_GB |
dc.subject | NIH 3T3 Cells | en_GB |
dc.subject | Toxicity Tests | en_GB |
dc.title | Galleria mellonella larvae allow the discrimination of toxic and non-toxic chemicals | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2018-11-12T15:38:49Z | |
exeter.place-of-publication | England | en_GB |
dc.description | This is the final version. Available from Elsevier via the DOI in this record | en_GB |
dc.identifier.journal | Chemosphere | en_GB |