dc.contributor.author | Lazzaretti, D | |
dc.contributor.author | Bono, F | |
dc.date.accessioned | 2018-11-14T14:14:56Z | |
dc.date.issued | 2017-07-01 | |
dc.description.abstract | Asymmetric localization of mRNAs is a widespread gene regulatory mechanism that is crucial for many cellular processes. The localization of a transcript involves multiple steps and requires several protein factors to mediate transport, anchoring and translational repression of the mRNA. Specific recognition of the localizing transcript is a key step that depends on linear or structured localization signals, which are bound by RNA-binding proteins. Genetic studies have identified many components involved in mRNA localization. However, mechanistic aspects of the pathway are still poorly understood. Here we provide an overview of structural studies that contributed to our understanding of the mechanisms underlying mRNA localization, highlighting open questions and future challenges. | en_GB |
dc.description.sponsorship | The authors are funded by the Max Planck Gesellshaft, the European Research Council under the European Union's Seventh Framework Program (FP7/2007-2013), ERC grant agreement no. 310957 and the Deutsche Forschungsgemeinschaft (BO3588/2-1 to F.B.). | en_GB |
dc.identifier.citation | Vol. 14 (11), pp. 1473 - 1484 | en_GB |
dc.identifier.doi | 10.1080/15476286.2017.1338231 | |
dc.identifier.uri | http://hdl.handle.net/10871/34765 | |
dc.language.iso | en | en_GB |
dc.publisher | Taylor & Francis | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/28640665 | en_GB |
dc.rights | © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_GB |
dc.subject | Drosophila; gene expression regulation | en_GB |
dc.subject | Post-transcriptional regulation | en_GB |
dc.subject | RBP | en_GB |
dc.subject | RNA localization | en_GB |
dc.subject | RNA-protein complexes | en_GB |
dc.subject | molecular mechanism | en_GB |
dc.subject | structure | en_GB |
dc.subject | trans-acting factors | en_GB |
dc.subject | Animals | en_GB |
dc.subject | Cell Cycle Proteins | en_GB |
dc.subject | Drosophila Proteins | en_GB |
dc.subject | Drosophila melanogaster | en_GB |
dc.subject | Eukaryotic Initiation Factor-4E | en_GB |
dc.subject | Gene Expression Regulation | en_GB |
dc.subject | Models, Molecular | en_GB |
dc.subject | Poly(A)-Binding Proteins | en_GB |
dc.subject | Protein Binding | en_GB |
dc.subject | Protein Biosynthesis | en_GB |
dc.subject | Protein Structure, Secondary | en_GB |
dc.subject | RNA Stability | en_GB |
dc.subject | RNA, Messenger | en_GB |
dc.title | mRNA localization in metazoans: A structural perspective | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2018-11-14T14:14:56Z | |
exeter.place-of-publication | United States | en_GB |
dc.description | This is the final version. Available on open access from Taylor & Francis via the DOI in this record | en_GB |
dc.identifier.journal | RNA Biology | en_GB |