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dc.contributor.authorPorteus, CS
dc.contributor.authorHubbard, PC
dc.contributor.authorUren Webster, TM
dc.contributor.authorvan Aerle, R
dc.contributor.authorCanário, AVM
dc.contributor.authorSantos, EM
dc.contributor.authorWilson, RW
dc.date.accessioned2018-11-22T12:03:56Z
dc.date.issued2018-07-23
dc.description.abstractSurvival of marine fishes that are exposed to elevated near-future CO2levels is threatened by their altered responses to sensory cues. Here we demonstrate a physiological and molecular mechanism in the olfactory system that helps to explain altered behaviour under elevated CO2. We combine electrophysiology measurements and transcriptomics with behavioural experiments to investigate how elevated CO2affects the olfactory system of European sea bass (Dicentrarchus labrax). When exposed to elevated CO2(approximately 1,000 µatm), fish must be up to 42% closer to an odour source for detection, compared with current CO2levels (around 400 µatm), decreasing their chances of detecting food or predators. Compromised olfaction correlated with the suppression of the transcription of genes involved in synaptic strength, cell excitability and wiring of the olfactory system in response to sustained exposure to elevated CO2levels. Our findings complement the previously proposed impairment of γ-aminobutyric acid receptors, and indicate that both the olfactory system and central brain function are compromised by elevated CO2levels.en_GB
dc.description.sponsorshipThis study was supported by grants from Association of European Marine Biology Laboratories (227799), the Natural Environment Research Council (R.W.W.; NE/H017402/1), the Biotechnology and Biological Sciences Research Council (R.W.W.; BB/D005108/1), Fundação para a Ciência e Tecnologia (Portuguese Science Ministry) (UID/Multi/04326/2013) and a Royal Society Newton International Fellowship to C.S.P. C.S.P. is also a beneficiary of a Starting Grant from AXA.en_GB
dc.identifier.citationVol. 8, pp. 737 - 743en_GB
dc.identifier.doi10.1038/s41558-018-0224-8
dc.identifier.urihttp://hdl.handle.net/10871/34865
dc.language.isoenen_GB
dc.publisherSpringer Natureen_GB
dc.rights.embargoreasonUnder embargo until 23 January 2019 in compliance with publisher policyen_GB
dc.rights© 2018, The Author(s).en_GB
dc.titleNear-future CO2 levels impair the olfactory system of a marine fishen_GB
dc.typeArticleen_GB
dc.identifier.issn1758-678X
dc.descriptionThis is the author accepted manuscript. The final version is available from Springer Nature via the DOI in this recorden_GB
dc.descriptionData availability: All raw sequence data are accessible at the NCBI Sequence Read Archive through accession number SRP097118. Water chemistry, behaviour and electrophysiology data are available through Pangaea (https://doi.pangaea.de/10.1594/PANGAEA.884674).en_GB
dc.identifier.journalNature Climate Changeen_GB
dcterms.dateAccepted2018-06-19


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