Rhythmic Oxygen Levels Reset Circadian Clocks through HIF1 alpha
dc.contributor.author | Adamovich, Y | |
dc.contributor.author | Ladeuix, B | |
dc.contributor.author | Golik, M | |
dc.contributor.author | Koeners, MP | |
dc.contributor.author | Asher, G | |
dc.date.accessioned | 2018-12-05T14:58:44Z | |
dc.date.issued | 2016-10-20 | |
dc.description.abstract | The mammalian circadian system consists of a master clock in the brain that synchronizes subsidiary oscillators in peripheral tissues. The master clock maintains phase coherence in peripheral cells through systemic cues such as feeding-fasting and temperature cycles. Here, we examined the role of oxygen as a resetting cue for circadian clocks. We continuously measured oxygen levels in living animals and detected daily rhythms in tissue oxygenation. Oxygen cycles, within the physiological range, were sufficient to synchronize cellular clocks in a HIF1α-dependent manner. Furthermore, several clock genes responded to changes in oxygen levels through HIF1α. Finally, we found that a moderate reduction in oxygen levels for a short period accelerates the adaptation of wild-type but not of HIF1α-deficient mice to the new time in a jet lag protocol. We conclude that oxygen, via HIF1α activation, is a resetting cue for circadian clocks and propose oxygen modulation as therapy for jet lag. | en_GB |
dc.description.sponsorship | Israel Science Foundation | en_GB |
dc.description.sponsorship | European Research Council | en_GB |
dc.description.sponsorship | Feinberg Graduate School, Weizmann Institute of Science | en_GB |
dc.description.sponsorship | British Heart Foundation | en_GB |
dc.description.sponsorship | European Union, Seventh Framework Programme | en_GB |
dc.identifier.citation | Vol. 25 (1), pp. 93 - 101 | en_GB |
dc.identifier.doi | 10.1016/j.cmet.2016.09.014 | |
dc.identifier.grantnumber | ISF 138/12 | en_GB |
dc.identifier.grantnumber | ERC-2011 METACYCLES 310320 | en_GB |
dc.identifier.grantnumber | FS/14/2/30630 | en_GB |
dc.identifier.grantnumber | ARPEDIEM - No. 612280 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/35009 | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier (Cell Press) | en_GB |
dc.rights | © 2016. This version is made available under the CC-BY-NC-ND 4.0 license: https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dc.subject | circadian rhythms | en_GB |
dc.subject | clock | en_GB |
dc.subject | oxygen | en_GB |
dc.subject | HIF1 | en_GB |
dc.subject | jetlag | en_GB |
dc.subject | metabolism | en_GB |
dc.subject | entrainment | en_GB |
dc.subject | Cry2 | en_GB |
dc.subject | Rorα | en_GB |
dc.title | Rhythmic Oxygen Levels Reset Circadian Clocks through HIF1 alpha | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2018-12-05T14:58:44Z | |
dc.identifier.issn | 1550-4131 | |
dc.description | This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record | en_GB |
dc.identifier.journal | Cell Metabolism | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dcterms.dateAccepted | 2016-09-23 | |
rioxxterms.version | AM | en_GB |
rioxxterms.licenseref.startdate | 2016-10-20 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2018-12-05T14:53:32Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2018-12-05T14:58:47Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © 2016. This version is made available under the CC-BY-NC-ND 4.0 license: https://creativecommons.org/licenses/by-nc-nd/4.0/