The Community Ageing Research 75+ Study (CARE75+): an experimental ageing and frailty research cohort
Heaven, A; Brown, L; Young, J; et al.Teale, E; Hawkins, R; Spilsbury, K; Mountain, G; Young, T; Goodwin, V; Hanratty, B; Chew-Graham, CA; Brundle, C; Mahmood, F; Jacob, I; Daffu-O'Reilly, A; Clegg, A
Date: 7 March 2019
Journal
BMJ Open
Publisher
BMJ Publishing Group
Publisher DOI
Abstract
Introduction: The Community Ageing Research 75+ Study (CARE75+) is a longitudinal cohort study collecting an extensive range of health, social and economic data, with a focus on frailty, independence and quality of life in older age. CARE75+ is the first international experimental frailty research cohort designed using Trial within ...
Introduction: The Community Ageing Research 75+ Study (CARE75+) is a longitudinal cohort study collecting an extensive range of health, social and economic data, with a focus on frailty, independence and quality of life in older age. CARE75+ is the first international experimental frailty research cohort designed using Trial within Cohort (TwiCs) methodology, to align applied epidemiological research with clinical trial evaluation of interventions to improve the health and wellbeing of older people living with frailty.
Methods and analysis: Prospective cohort study using a trial within cohort (TwiCs) design. One thousand community-dwelling older people (≥75years) will be recruited from UK general practices. Nursing home residents, those with an estimated life expectancy of three months or less and people receiving palliative care will be excluded. Data collection assessments will be face-to-face in the person’s home at baseline, six months, 12 months, 24 month and 48 months, including assessments of frailty, cognition, mood, health-related quality of life, comorbidity, medications, resilience, loneliness, pain and self-efficacy. A modified protocol for follow-up by telephone or web-based will be offered at six months. Consent will be sought for data linkage and invitations to additional studies, including intervention studies using the TwiCs design. A blood sample bio-bank will be established for future basic science studies.
Institute of Health Research
Collections of Former Colleges
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