Show simple item record

dc.contributor.authorTyrrell, J
dc.contributor.authorPaterson, C
dc.contributor.authorCurnow, A
dc.date.accessioned2019-01-30T11:56:19Z
dc.date.issued2019-01-30
dc.description.abstractPhotodynamic therapy (PDT) is a light activated drug therapy that can be used to treat a number of dermatological cancers and precancers. Improvement of efficacy is required to widen its application. Clinical protoporphyrin IX (PpIX) fluorescence data were obtained using a pre-validated, non-invasive imaging system during routine methyl aminolevulinate (MAL)-PDT treatment of 172 patients with licensed dermatological indications (37.2% actinic keratosis, 27.3% superficial basal cell carcinoma and 35.5% Bowen’s disease). Linear and logistic regressions were employed to model any relationships between variables that may have affected PpIX accumulation and/or PpIX photobleaching during irradiation and thus clinical outcome at three months. Patient age was found to be associated with lower PpIX accumulation/photobleaching, however only a reduction in PpIX photobleaching appeared to consistently adversely affect treatment efficacy. Clinical clearance was reduced in lesions located on the limbs, hands and feet with lower PpIX accumulation and subsequent photobleaching adversely affecting the outcome achieved. If air cooling pain relief was employed during light irradiation, PpIX photobleaching was lower and this resulted in an approximate three-fold reduction in the likelihood of achieving clinical clearance. PpIX photobleaching during the first treatment was concluded to be an excellent predictor of clinical outcome across all lesion types.en_GB
dc.description.sponsorshipKilling Canceren_GB
dc.description.sponsorshipDuchy Health Charity Trusten_GB
dc.formatxlsen_GB
dc.identifier.doi10.24378/exe.1103
dc.identifier.urihttp://hdl.handle.net/10871/35642
dc.language.isoenen_GB
dc.publisherUniversity of Exeteren_GB
dc.relation.urlhttp://hdl.handle.net/10871/35475en_GB
dc.rightsCC BY 4.0en_GB
dc.titleRegression analysis of protoporphyrin IX measurements obtained during dermatological photodynamic therapy (dataset)en_GB
dc.typeDataseten_GB
dc.date.available2019-01-30T11:56:19Z
dc.descriptionThis is the Excel dataset (n=172) utilised to produce the results for the Tyrrell et al. (2019) article "Regression analysis of protoporphyrin IX measurements obtained during dermatological photodynamic therapy" published in the Cancers journal.en_GB
dc.descriptionThe article associated with this dataset is located in ORE at: http://hdl.handle.net/10871/35475en_GB
dc.identifier.journalCancersen_GB
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_GB
dcterms.dateAccepted2019-01-30
exeter.funder::Killing Canceren_GB
exeter.funder::Duchy Health Charity Trusten_GB
rioxxterms.versionNAen_GB
rioxxterms.typeOtheren_GB
refterms.dateFOA2019-01-30T11:56:22Z


Files in this item

This item appears in the following Collection(s)

Show simple item record

CC BY 4.0
Except where otherwise noted, this item's licence is described as CC BY 4.0