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Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study

dc.contributor.authorBudu-Aggrey, A
dc.contributor.authorBrumpton, B
dc.contributor.authorTyrrell, J
dc.contributor.authorWatkins, S
dc.contributor.authorModasli, E
dc.contributor.authorCelis-Morales, C
dc.contributor.authorFerguson, L
dc.contributor.authorVie, G
dc.contributor.authorPalmer, T
dc.contributor.authorFritsche, L
dc.contributor.authorLoset, M
dc.contributor.authorNielsen, J
dc.contributor.authorZhou, W
dc.contributor.authorTsoi, L
dc.contributor.authorWood, A
dc.contributor.authorJones, S
dc.contributor.authorBeaumont, R
dc.contributor.authorSaunes, M
dc.contributor.authorRomundstad, P
dc.contributor.authorSiebert, S
dc.contributor.authorMcInnes, I
dc.contributor.authorElder, J
dc.contributor.authorDavey Smith, G
dc.contributor.authorFrayling, T
dc.contributor.authorAsvold, B
dc.contributor.authorBrown, S
dc.contributor.authorSattar, N
dc.contributor.authorPaternoster, L
dc.date.accessioned2019-02-07T08:55:37Z
dc.date.issued2019-01-31
dc.description.abstractBackground Psoriasis is a common inflammatory skin disease that has been reported to be associated with obesity. We aimed to investigate a possible causal relationship between body mass index (BMI) and psoriasis.en_GB
dc.description.sponsorshipEuropean Regional Development Fund (ERDF)en_GB
dc.description.sponsorshipDiabetes Research and Wellness Foundationen_GB
dc.identifier.citationVol. 16 (1): e1002739en_GB
dc.identifier.doi10.1371/journal.pmed.1002739
dc.identifier.urihttp://hdl.handle.net/10871/35772
dc.language.isoenen_GB
dc.publisherPublic Library of Science (PLoS)en_GB
dc.relation.urlhttp://www.ukbiobank.ac.uk/scientists-3/en_GB
dc.relation.urlhttp://www.ntnu.edu/hunt/dataen_GB
dc.relation.urlhttps://portals.broadinstitute.org/collaboration/giant/index.php/GIANT_consortium_data_files#GWAS_Anthropometric_2015_BMIen_GB
dc.rights© The Author(s). Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. en_GB
dc.titleEvidence of a causal relationship between body mass index and psoriasis: A mendelian randomization studyen_GB
dc.typeArticleen_GB
dc.date.available2019-02-07T08:55:37Z
dc.identifier.issn1549-1277
dc.descriptionThis is the author accepted manuscript. The final version is available from PLoS via the DOI in this record en_GB
dc.descriptionData Availability: The UK Biobank dataset used to conduct the research in this paper is available via application directly to the UK Biobank. Applications are assessed for meeting the required criteria for access, including legal and ethics standards. More information regarding data access can be found here: http://www.ukbiobank.ac.uk/scientists-3/. Data from the HUNT Study used in research projects will, when reasonably requested by others, be made available upon request to the HUNT Data Access Committee (hunt@medisin.ntnu.no). Data are only available to research groups with a PI affiliated with a Norwegian research institute. The HUNT data access information (available here: http://www.ntnu.edu/hunt/data) describes in detail the policy regarding data availability. BMI GWAS source data (Locke et al, 2015) are available from the GIANT consortium (https://portals.broadinstitute.org/collaboration/giant/index.php/GIANT_consortium_data_files#GWAS_Anthropometric_2015_BMI). Psoriasis GWAS source data used in this study have been made available in S1 Appendix. This research has been conducted using data from the UK Biobank Resource (application numbers 10074 and 9072) and the Nord-Trøndelag Health Study (the HUNT Study).en_GB
dc.identifier.journalPLoS Medicineen_GB
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2018-12-19
rioxxterms.versionAMen_GB
rioxxterms.licenseref.startdate2019-01-31
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2019-02-05T12:04:45Z
refterms.versionFCDAM
refterms.dateFOA2019-02-07T08:55:42Z
refterms.panelAen_GB
refterms.dateFirstOnline2019-01-31


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© The Author(s). Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. 
Except where otherwise noted, this item's licence is described as © The Author(s). Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.