Interaction of the hydrogen sulfide system with the oxytocin system in the injured mouse heart.
dc.contributor.author | Merz, T | |
dc.contributor.author | Lukaschewski, B | |
dc.contributor.author | Wigger, D | |
dc.contributor.author | Rupprecht, A | |
dc.contributor.author | Wepler, M | |
dc.contributor.author | Gröger, M | |
dc.contributor.author | Hartmann, C | |
dc.contributor.author | Whiteman, M | |
dc.contributor.author | Szabo, C | |
dc.contributor.author | Wang, R | |
dc.contributor.author | Waller, C | |
dc.contributor.author | Radermacher, P | |
dc.contributor.author | McCook, O | |
dc.date.accessioned | 2019-02-11T14:04:00Z | |
dc.date.issued | 2018-10-19 | |
dc.description.abstract | BACKGROUND: Both the hydrogen sulfide/cystathionine-γ-lyase (H2S/CSE) and oxytocin/oxytocin receptor (OT/OTR) systems have been reported to be cardioprotective. H2S can stimulate OT release, thereby affecting blood volume and pressure regulation. Systemic hyper-inflammation after blunt chest trauma is enhanced in cigarette smoke (CS)-exposed CSE-/- mice compared to wildtype (WT). CS increases myometrial OTR expression, but to this point, no data are available on the effects CS exposure on the cardiac OT/OTR system. Since a contusion of the thorax (Txt) can cause myocardial injury, the aim of this post hoc study was to investigate the effects of CSE-/- and exogenous administration of GYY4137 (a slow release H2S releasing compound) on OTR expression in the heart, after acute on chronic disease, of CS exposed mice undergoing Txt. METHODS: This study is a post hoc analysis of material obtained in wild type (WT) homozygous CSE-/- mice after 2-3 weeks of CS exposure and subsequent anesthesia, blast wave-induced TxT, and surgical instrumentation for mechanical ventilation (MV) and hemodynamic monitoring. CSE-/- animals received a 50 μg/g GYY4137-bolus after TxT. After 4h of MV, animals were exsanguinated and organs were harvested. The heart was cut transversally, formalin-fixed, and paraffin-embedded. Immunohistochemistry for OTR, arginine-vasopressin-receptor (AVPR), and vascular endothelial growth factor (VEGF) was performed with naïve animals as native controls. RESULTS: CSE-/- was associated with hypertension and lower blood glucose levels, partially and significantly restored by GYY4137 treatment, respectively. Myocardial OTR expression was reduced upon injury, and this was aggravated in CSE-/-. Exogenous H2S administration restored myocardial protein expression to WT levels. CONCLUSIONS: This study suggests that cardiac CSE regulates cardiac OTR expression, and this effect might play a role in the regulation of cardiovascular function. | en_GB |
dc.description.sponsorship | German Research Foundation | en_GB |
dc.description.sponsorship | IGradU | en_GB |
dc.description.sponsorship | Ulm University (Herta-Narthorff-Programm) | en_GB |
dc.identifier.citation | Vol. 6: 41 | en_GB |
dc.identifier.doi | 10.1186/s40635-018-0207-0 | |
dc.identifier.grantnumber | CRC1149 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/35897 | |
dc.language.iso | en | en_GB |
dc.publisher | SpringerOpen / Springer Verlag / European Society of Intensive Care Medicine (ESICM) | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/30341744 | en_GB |
dc.rights | © The Author(s). 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | en_GB |
dc.subject | Arginine-vasopressin receptor | en_GB |
dc.subject | Blood glucose | en_GB |
dc.subject | Cardiovascular system | en_GB |
dc.subject | Cystathionine-γ-lyase | en_GB |
dc.subject | GYY4137 | en_GB |
dc.subject | Vascular endothelial growth factor | en_GB |
dc.title | Interaction of the hydrogen sulfide system with the oxytocin system in the injured mouse heart. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2019-02-11T14:04:00Z | |
dc.identifier.issn | 2197-425X | |
exeter.place-of-publication | Germany | en_GB |
dc.description | This is the final version. Available from the publisher via the DOI in this record. | en_GB |
dc.identifier.journal | Intensive Care Medicine Experimental | en_GB |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2018-10-07 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2018-10-19 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2019-02-11T13:27:04Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2019-02-11T14:04:04Z | |
refterms.panel | A | en_GB |
refterms.depositException | publishedGoldOA | |
refterms.depositExceptionExplanation | https://doi.org/10.1186/s40635-018-0207-0 |
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Except where otherwise noted, this item's licence is described as © The Author(s). 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.