Oxygen and Carbon Dioxide Rhythms Are Circadian Clock Controlled and Differentially Directed by Behavioral Signals
dc.contributor.author | Adamovich, Y | |
dc.contributor.author | Ladeuix, B | |
dc.contributor.author | Sobel, J | |
dc.contributor.author | Manella, G | |
dc.contributor.author | Neufeld-Cohen, A | |
dc.contributor.author | Assadi, MH | |
dc.contributor.author | Golik, M | |
dc.contributor.author | Kuperman, Y | |
dc.contributor.author | Tarasiuk, A | |
dc.contributor.author | Koeners, MPM | |
dc.contributor.author | Asher, G | |
dc.date.accessioned | 2019-02-18T11:14:24Z | |
dc.date.issued | 2019-02-14 | |
dc.description.abstract | Daily rhythms in animal physiology are driven by endogenous circadian clocks in part through rest-activity and feeding-fasting cycles. Here, we examined principles that govern daily respiration. We monitored oxygen consumption and carbon dioxide release, as well as tissue oxygenation in freely moving animals to specifically dissect the role of circadian clocks and feeding time on daily respiration. We found that daily rhythms in oxygen and carbon dioxide are clock controlled and that time-restricted feeding restores their rhythmicity in clock-deficient mice. Remarkably, day-time feeding dissociated oxygen rhythms from carbon dioxide oscillations, whereby oxygen followed activity, and carbon dioxide was shifted and aligned with food intake. In addition, changes in carbon dioxide levels altered clock gene expression and phase shifted the clock. Collectively, our findings indicate that oxygen and carbon dioxide rhythms are clock controlled and feeding regulated and support a potential role for carbon dioxide in phase resetting peripheral clocks upon feeding. | en_GB |
dc.description.sponsorship | British Heart Foundation | en_GB |
dc.description.sponsorship | European Research Council | en_GB |
dc.description.sponsorship | European Union, Seventh Framework Program, Marie Curie Actions | en_GB |
dc.identifier.citation | Vol. 29, pp. 1 - 12 | en_GB |
dc.identifier.doi | 10.1016/j.cmet.2019.01.007 | |
dc.identifier.grantnumber | FS/14/2/30360 | en_GB |
dc.identifier.grantnumber | ERC-2017 CIRCOMMUNICATION 770869 | en_GB |
dc.identifier.grantnumber | CARPEDIEM – No. 612280 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/35972 | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier (Cell Press) | en_GB |
dc.rights.embargoreason | Under embargo until 14 February 2019 in compliance with publisher policy. | |
dc.rights | © 2019 Elsevier Inc. This version is made available under the CC-BY-NC-ND 4.0 license: https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dc.subject | circadian clocks | en_GB |
dc.subject | oxygen | en_GB |
dc.subject | carbon dioxide | en_GB |
dc.subject | respiration | en_GB |
dc.subject | time restricted feeding | en_GB |
dc.subject | metabolism | en_GB |
dc.subject | metabolic cages | en_GB |
dc.subject | phase resetting | en_GB |
dc.title | Oxygen and Carbon Dioxide Rhythms Are Circadian Clock Controlled and Differentially Directed by Behavioral Signals | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2019-02-18T11:14:24Z | |
dc.identifier.issn | 1932-7420 | |
dc.description | This is the author accepted manuscript. The final version is available from Elsevier (Cell Press). | en_GB |
dc.identifier.journal | Cell Metabolism | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dcterms.dateAccepted | 2019-01-16 | |
exeter.funder | ::British Heart Foundation | en_GB |
rioxxterms.version | AM | en_GB |
rioxxterms.licenseref.startdate | 2019-02-14 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2019-02-15T16:08:37Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2019-02-14T00:00:00Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © 2019 Elsevier Inc. This version is made available under the CC-BY-NC-ND 4.0 license: https://creativecommons.org/licenses/by-nc-nd/4.0/