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dc.contributor.authorHan, Y
dc.contributor.authorvan Houte, S
dc.contributor.authorDrees, GF
dc.contributor.authorvan Oers, MM
dc.contributor.authorRos, VID
dc.date.accessioned2019-03-04T10:39:00Z
dc.date.issued2015-07-31
dc.description.abstractMany parasites enhance their dispersal and transmission by manipulating host behaviour. One intriguing example concerns baculoviruses that induce hyperactivity and tree-top disease (i.e., climbing to elevated positions prior to death) in their caterpillar hosts. Little is known about the underlying mechanisms of such parasite-induced behavioural changes. Here, we studied the role of the ecdysteroid UDP-glucosyltransferase (egt) gene of Spodoptera exigua multiple nucleopolyhedrovirus (SeMNPV) in tree-top disease in S. exigua larvae. Larvae infected with a mutant virus lacking the egt gene exhibited a shorter time to death and died before the induction of tree-top disease. Moreover, deletion of either the open reading frame or the ATG start codon of the egt gene prevented tree-top disease, indicating that the EGT protein is involved in this process. We hypothesize that SeMNPV EGT facilitates tree-top disease in S. exigua larvae by prolonging the larval time to death. Additionally, we discuss the role of egt in baculovirus-induced tree-top disease.en_GB
dc.description.sponsorshipProgram Strategic Alliances of the Royal Dutch Academy of Sciencesen_GB
dc.description.sponsorshipNetherlands Organization for Scientific Researchen_GB
dc.identifier.citationVol. 6, pp. 716 - 731en_GB
dc.identifier.doi10.3390/insects6030716
dc.identifier.grantnumber08-PSA-BD-01en_GB
dc.identifier.grantnumber863.11.017en_GB
dc.identifier.urihttp://hdl.handle.net/10871/36218
dc.language.isoenen_GB
dc.publisherMDPIen_GB
dc.rights© 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).en_GB
dc.subjectbehavioural manipulationen_GB
dc.subjectbaculovirusen_GB
dc.subjecttree-top diseaseen_GB
dc.subjectSeMNPVen_GB
dc.subjectegt geneen_GB
dc.subjectSpodoptera exiguaen_GB
dc.titleParasitic manipulation of host behaviour: Baculovirus SeMNPV EGT facilitates tree-top disease in spodoptera exigua larvae by extending the time to deathen_GB
dc.typeArticleen_GB
dc.date.available2019-03-04T10:39:00Z
dc.identifier.issn2075-4450
dc.descriptionThis is the final version. Available from the publisher via the DOI in this record.en_GB
dc.identifier.journalInsectsen_GB
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_GB
pubs.euro-pubmed-idMED:26463412
dcterms.dateAccepted2015-07-27
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2015-07-31
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2019-03-04T10:35:09Z
refterms.versionFCDVoR
refterms.dateFOA2019-03-04T10:39:02Z
refterms.panelAen_GB


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© 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article
distributed under the terms and conditions of the Creative Commons Attribution license
(http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's licence is described as © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).