Parasitic manipulation of host behaviour: Baculovirus SeMNPV EGT facilitates tree-top disease in spodoptera exigua larvae by extending the time to death
dc.contributor.author | Han, Y | |
dc.contributor.author | van Houte, S | |
dc.contributor.author | Drees, GF | |
dc.contributor.author | van Oers, MM | |
dc.contributor.author | Ros, VID | |
dc.date.accessioned | 2019-03-04T10:39:00Z | |
dc.date.issued | 2015-07-31 | |
dc.description.abstract | Many parasites enhance their dispersal and transmission by manipulating host behaviour. One intriguing example concerns baculoviruses that induce hyperactivity and tree-top disease (i.e., climbing to elevated positions prior to death) in their caterpillar hosts. Little is known about the underlying mechanisms of such parasite-induced behavioural changes. Here, we studied the role of the ecdysteroid UDP-glucosyltransferase (egt) gene of Spodoptera exigua multiple nucleopolyhedrovirus (SeMNPV) in tree-top disease in S. exigua larvae. Larvae infected with a mutant virus lacking the egt gene exhibited a shorter time to death and died before the induction of tree-top disease. Moreover, deletion of either the open reading frame or the ATG start codon of the egt gene prevented tree-top disease, indicating that the EGT protein is involved in this process. We hypothesize that SeMNPV EGT facilitates tree-top disease in S. exigua larvae by prolonging the larval time to death. Additionally, we discuss the role of egt in baculovirus-induced tree-top disease. | en_GB |
dc.description.sponsorship | Program Strategic Alliances of the Royal Dutch Academy of Sciences | en_GB |
dc.description.sponsorship | Netherlands Organization for Scientific Research | en_GB |
dc.identifier.citation | Vol. 6, pp. 716 - 731 | en_GB |
dc.identifier.doi | 10.3390/insects6030716 | |
dc.identifier.grantnumber | 08-PSA-BD-01 | en_GB |
dc.identifier.grantnumber | 863.11.017 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/36218 | |
dc.language.iso | en | en_GB |
dc.publisher | MDPI | en_GB |
dc.rights | © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). | en_GB |
dc.subject | behavioural manipulation | en_GB |
dc.subject | baculovirus | en_GB |
dc.subject | tree-top disease | en_GB |
dc.subject | SeMNPV | en_GB |
dc.subject | egt gene | en_GB |
dc.subject | Spodoptera exigua | en_GB |
dc.title | Parasitic manipulation of host behaviour: Baculovirus SeMNPV EGT facilitates tree-top disease in spodoptera exigua larvae by extending the time to death | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2019-03-04T10:39:00Z | |
dc.identifier.issn | 2075-4450 | |
dc.description | This is the final version. Available from the publisher via the DOI in this record. | en_GB |
dc.identifier.journal | Insects | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
pubs.euro-pubmed-id | MED:26463412 | |
dcterms.dateAccepted | 2015-07-27 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2015-07-31 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2019-03-04T10:35:09Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2019-03-04T10:39:02Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article
distributed under the terms and conditions of the Creative Commons Attribution license
(http://creativecommons.org/licenses/by/4.0/).