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dc.contributor.authorMasoli, J
dc.contributor.authorCorrea Delgado, J
dc.contributor.authorBowman, K
dc.contributor.authorStrain, W
dc.contributor.authorHenley, W
dc.contributor.authorMelzer, D
dc.date.accessioned2019-03-04T13:50:32Z
dc.date.issued2019-02-28
dc.description.abstractBackground: in chronic kidney disease (CKD), hypertension is associated with poor outcomes at ages <70 years. At older ages, this association is unclear. We tested 10-year mortality and cardiovascular outcomes by clinical systolic blood pressure (SBP) in older CKD Stages 3 and 4 patients without diabetes or proteinuria. Methods: retrospective cohort in population representative primary care electronic medical records linked to hospital data from the UK. CKD staged by CKD-EPI equation (≥2 creatinine measurements ≥90 days apart). SBPs were 3-year medians before baseline, with mean follow-up 5.7 years. Cox competing models accounted for mortality. Results: about 158,713 subjects with CKD3 and 6,611 with CKD4 met inclusion criteria. Mortality increased with increasing CKD stage in all subjects aged >60. In the 70 plus group with SBPs 140–169 mmHg, there was no increase in mortality, versus SBP 130–139. Similarly, SBPs 140–169 mmHg were not associated with increased incident heart failure, stroke or myocardial infarctions. SBPs <120 mmHg were associated with increased mortality and cardiovascular risk. At ages 60–69, there was increased mortality at SBP <120 and SBP >150 mmHg. Results were little altered after excluding those with declining SBPs during 5 years before baseline, or for longer-term outcomes (5–10 years after baseline). Conclusions: in older primary care patients, CKD3 or 4 was the dominant outcome predictor. SBP 140–169 mmHg having little additional predictive value, <120 mmHg was associated with increased mortality. Prospective studies of representative older adults with CKD are required to establish optimum BP targets.en_GB
dc.description.sponsorshipNational Institute for Health Research (NIHR)en_GB
dc.identifier.citationPublished online 28 February 2019en_GB
dc.identifier.doi10.1093/ageing/afz006
dc.identifier.grantnumberDRF-2014-07-177en_GB
dc.identifier.urihttp://hdl.handle.net/10871/36239
dc.language.isoenen_GB
dc.publisherOxford University Press (OUP)en_GB
dc.rights© The Author(s) 2019. Published by Oxford University Press on behalf of the British Geriatrics Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.comen_GB
dc.subjectblood pressureen_GB
dc.subjectchronic kidney diseaseen_GB
dc.subjectolder peopleen_GB
dc.subjectcardiovascular outcomesen_GB
dc.titleAssociation of blood pressure with clinical outcomes in older adults with chronic kidney diseaseen_GB
dc.typeArticleen_GB
dc.date.available2019-03-04T13:50:32Z
dc.identifier.issn0002-0729
dc.descriptionThis is the final version. Available from the publisher via the DOI in this record.en_GB
dc.identifier.journalAge and Ageingen_GB
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/en_GB
dcterms.dateAccepted2019-01-14
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2019-02-28
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2019-03-04T13:47:22Z
refterms.versionFCDVoR
refterms.dateFOA2019-03-04T13:50:35Z
refterms.panelAen_GB


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© The Author(s) 2019. Published by Oxford University Press on behalf of the British Geriatrics Society.
This is an Open Access article distributed under the terms of the Creative Commons Attribution NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For
commercial re-use, please contact journals.permissions@oup.com
Except where otherwise noted, this item's licence is described as © The Author(s) 2019. Published by Oxford University Press on behalf of the British Geriatrics Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com