New evidence on the management of Lewy body dementia
dc.contributor.author | Taylor, JP | |
dc.contributor.author | McKeith, IG | |
dc.contributor.author | Burn, D | |
dc.contributor.author | Boeve, B | |
dc.contributor.author | Weintraub, D | |
dc.contributor.author | Bamford, C | |
dc.contributor.author | Allan, LM | |
dc.contributor.author | Thomas, AJ | |
dc.contributor.author | O’Brien, JT | |
dc.date.accessioned | 2019-03-18T11:27:24Z | |
dc.date.issued | 2019-09-10 | |
dc.description.abstract | Dementia with Lewy bodies and Parkinson’s disease dementia, jointly known as Lewy body dementia (LBD), are common neurodegenerative conditions. Patients with LBD present with a wide range of cognitive, neuropsychiatric, sleep, motor, and autonomic symptoms. The expression of these varies between individual patients, and over time. Treatments may benefit one symptom, but at the expense of worsening another, making management difficult. Often symptoms are managed in isolation and by different specialists, which undermines high quality care. Clinical trials and meta-analyses now provide an improved evidence base for the treatment of cognitive, neuropsychiatric and motor symptoms in LBD, in addition to which expert consensus opinion supports the application of treatments from related conditions such as Parkinson’s disease (PD) for the management of, for example, autonomic symptoms. There remain however clear evidence gaps and there is a high need for future clinical trials focused on specific symptoms in LBD. | en_GB |
dc.description.sponsorship | National Institute for Health Research (NIHR) | en_GB |
dc.identifier.citation | Published online 10 September 2019 | en_GB |
dc.identifier.doi | 10.1016/S1474-4422(19)30153-X | |
dc.identifier.grantnumber | DTC-RP-PG-0311-12001 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/36535 | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.rights.embargoreason | Under embargo until 10 March 2020 in compliance with publisher policy | |
dc.rights | © 2019. This version is made available under the CC-BY-NC-ND 4.0 license: https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | New evidence on the management of Lewy body dementia | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2019-03-18T11:27:24Z | |
dc.identifier.issn | 1474-4422 | |
dc.description | This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record | en_GB |
dc.description | Note that the article title of the accepted author manuscript is different to that of the final published version. | |
dc.identifier.journal | Lancet Neurology | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dcterms.dateAccepted | 2019-03-14 | |
rioxxterms.version | AM | en_GB |
rioxxterms.licenseref.startdate | 2019-03-14 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2019-03-18T10:44:19Z | |
refterms.versionFCD | AM | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © 2019. This version is made available under the CC-BY-NC-ND 4.0 license: https://creativecommons.org/licenses/by-nc-nd/4.0/