Host-pathogen coevolution increases genetic variation in susceptibility to infection
dc.contributor.author | Duxbury, E | |
dc.contributor.author | Day, J | |
dc.contributor.author | Vespasiani, D | |
dc.contributor.author | Thüringer, Y | |
dc.contributor.author | Tolosana, I | |
dc.contributor.author | Smith, S | |
dc.contributor.author | Tagliaferri, L | |
dc.contributor.author | Kamacioglu, A | |
dc.contributor.author | Lindsley, I | |
dc.contributor.author | Love, L | |
dc.contributor.author | Unckless, R | |
dc.contributor.author | Jiggins, F | |
dc.contributor.author | Longdon, B | |
dc.date.accessioned | 2019-04-12T15:20:01Z | |
dc.date.issued | 2019-04-30 | |
dc.description.abstract | It is common to find considerable genetic variation in susceptibility to infection in natural populations. We have investigated whether natural selection increases this variation by testingwhether host populations show more genetic variation in susceptibility to pathogens that they naturally encounter than novel pathogens. In a large cross-infection experiment involving four species of Drosophila and four host-specific viruses, we always found greater genetic variation in susceptibility to viruses that had coevolved with their host. We went on to examine the genetic architecture of resistance in one host species, finding thatthere are more major-effect genetic variants in coevolved host-pathogeninteractions. We conclude that selection by pathogens has increased genetic variation in host susceptibility,and much of this effect is caused by the occurrence of major-effect resistance polymorphisms within populations. | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | Natural Environment Research Council | en_GB |
dc.description.sponsorship | European Research Council | en_GB |
dc.identifier.citation | Vol. 8, article e46440 | en_GB |
dc.identifier.doi | 10.7554/eLife.46440.001 | |
dc.identifier.grantnumber | 109356/Z/15/Z | en_GB |
dc.identifier.grantnumber | NE/L004232/1 | en_GB |
dc.identifier.grantnumber | 281668 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/36799 | |
dc.language.iso | en | en_GB |
dc.publisher | eLife Sciences Publications Ltd | en_GB |
dc.relation.url | https://doi.org/10.6084/m9.figshare.6743339 | en_GB |
dc.relation.url | https://doi.org/10.6084/m9.figshare.6743354 | en_GB |
dc.relation.url | https://doi.org/10.6084/m9.figshare.7195751 | en_GB |
dc.rights | © 2019, Duxbury et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. | en_GB |
dc.title | Host-pathogen coevolution increases genetic variation in susceptibility to infection | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2019-04-12T15:20:01Z | |
dc.identifier.issn | 2050-084X | |
dc.description | This is the final version. Available on open access from eLife Sciences Publications via the DOI in this record | en_GB |
dc.description | Data availability: Datasets and R code for estimating the amount of genetic variation in susceptibility https://doi.org/10.6084/m9.figshare.6743339 DGRP dataset https://doi.org/10.6084/m9.figshare.6743354 DSPR dataset and R codehttps://doi.org/10.6084/m9.figshare.7195751 | en_GB |
dc.identifier.journal | eLife | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2019-04-07 | |
exeter.funder | ::Wellcome Trust | en_GB |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2019-04-08 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2019-04-12T14:07:45Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2019-05-14T11:06:15Z | |
refterms.panel | A | en_GB |
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This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.