dc.contributor.author | MacDonald, AJ | |
dc.contributor.author | Robb, JL | |
dc.contributor.author | Morrissey, NA | |
dc.contributor.author | Beall, C | |
dc.contributor.author | Ellacott, KLJ | |
dc.date.accessioned | 2019-05-09T09:15:20Z | |
dc.date.issued | 2019-05-03 | |
dc.description.abstract | A class of glial cell, astrocytes are highly abundant in the CNS. In addition to maintaining tissue homeostasis, astrocytes regulate neuronal communication and synaptic plasticity. There is an ever-increasing appreciation that astrocytes are involved in the regulation of physiology and behaviour in normal and pathological states, including within neuroendocrine systems. Indeed, astrocytes are direct targets of hormone action in the CNS, via receptors expressed on their surface, and are also a source of regulatory neuropeptides, neurotransmitters, and gliotransmitters. Furthermore, as part of the neurovascular unit, astrocytes can regulate hormone entry into the CNS. This review is intended to provide an overview of how astrocytes are impacted by and contribute to the regulation of a diverse range of neuroendocrine systems: energy homeostasis and metabolism, reproduction, fluid homeostasis, the stress response, and circadian rhythms. This article is protected by copyright. All rights reserved. | en_GB |
dc.description.sponsorship | Medical Research Council (MRC) | en_GB |
dc.description.sponsorship | Diabetes UK | en_GB |
dc.description.sponsorship | University of Exeter | en_GB |
dc.identifier.citation | Published online 3 May 2019 | en_GB |
dc.identifier.doi | 10.1111/jne.12726 | |
dc.identifier.grantnumber | MR/N012763/1 | en_GB |
dc.identifier.grantnumber | 13/0004647 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/37003 | |
dc.language.iso | en | en_GB |
dc.publisher | Wiley for European Neuroendocrine Association | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/31050045 | en_GB |
dc.rights.embargoreason | Under embargo until 3 May 2020 in compliance with publisher policy | en_GB |
dc.rights | © 2019 Wiley. All rights reserved | en_GB |
dc.subject | astrocyte | en_GB |
dc.subject | circadian | en_GB |
dc.subject | hypothalamus | en_GB |
dc.subject | metabolism | en_GB |
dc.subject | reproduction | en_GB |
dc.subject | stress | en_GB |
dc.title | Astrocytes in neuroendocrine systems: An overview | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2019-05-09T09:15:20Z | |
exeter.place-of-publication | United States | en_GB |
dc.description | This is the author accepted manuscript. The final version is available from Wiley via the DOI in this record | en_GB |
dc.identifier.eissn | 1365-2826 | |
dc.identifier.journal | Journal of Neuroendocrinology | en_GB |
dc.rights.uri | http://www.rioxx.net/licenses/all-rights-reserved | en_GB |
dcterms.dateAccepted | 2019-05-03 | |
exeter.funder | ::Medical Research Council (MRC) | en_GB |
rioxxterms.version | AM | en_GB |
rioxxterms.licenseref.startdate | 2019-05-03 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2019-05-09T09:12:33Z | |
refterms.versionFCD | AM | |
refterms.panel | A | en_GB |