Alternative Splicing in Angiogenesis
dc.contributor.author | Bowler, E | |
dc.contributor.author | Oltean, S | |
dc.date.accessioned | 2019-05-20T07:53:26Z | |
dc.date.issued | 2019-04-26 | |
dc.description.abstract | Alternative splicing of pre-mRNA allows the generation of multiple splice isoforms from a given gene, which can have distinct functions. In fact, splice isoforms can have opposing functions and there are many instances whereby a splice isoform acts as an inhibitor of canonical isoform function, thereby adding an additional layer of regulation to important processes. Angiogenesis is an important process that is governed by alternative splicing mechanisms. This review focuses on the alternative spliced isoforms of key genes that are involved in the angiogenesis process; VEGF-A, VEGFR1, VEGFR2, NRP-1, FGFRs, Vasohibin-1, Vasohibin-2, HIF-1α, Angiopoietin-1 and Angiopoietin-2. | en_GB |
dc.description.sponsorship | British Heart Foundation | en_GB |
dc.description.sponsorship | Diabetes UK | en_GB |
dc.identifier.citation | Vol. 20 (9) 2067 | en_GB |
dc.identifier.doi | 10.3390/ijms20092067 | |
dc.identifier.grantnumber | PG/15/53/31371 | en_GB |
dc.identifier.grantnumber | 17/0005668 | en_GB |
dc.identifier.other | ijms20092067 | |
dc.identifier.uri | http://hdl.handle.net/10871/37140 | |
dc.language.iso | en | en_GB |
dc.publisher | MDPI | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/31027366 | en_GB |
dc.rights | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | en_GB |
dc.subject | FGFR | en_GB |
dc.subject | HIF-1 | en_GB |
dc.subject | NRP | en_GB |
dc.subject | VEGF | en_GB |
dc.subject | VEGFR | en_GB |
dc.subject | alternative splicing | en_GB |
dc.subject | angiogenesis | en_GB |
dc.subject | angiopoietin | en_GB |
dc.subject | vasohibin | en_GB |
dc.title | Alternative Splicing in Angiogenesis | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2019-05-20T07:53:26Z | |
exeter.place-of-publication | Switzerland | en_GB |
dc.description | This is the final version. Available from MDPI via the DOI in this record. | en_GB |
dc.identifier.journal | International Journal of Molecular Sciences | en_GB |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2019-04-23 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2019-04-26 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2019-05-20T07:49:56Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2019-05-20T07:53:29Z | |
refterms.panel | A | en_GB |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's licence is described as © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).