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dc.contributor.authorBowler, E
dc.contributor.authorOltean, S
dc.date.accessioned2019-05-20T07:53:26Z
dc.date.issued2019-04-26
dc.description.abstractAlternative splicing of pre-mRNA allows the generation of multiple splice isoforms from a given gene, which can have distinct functions. In fact, splice isoforms can have opposing functions and there are many instances whereby a splice isoform acts as an inhibitor of canonical isoform function, thereby adding an additional layer of regulation to important processes. Angiogenesis is an important process that is governed by alternative splicing mechanisms. This review focuses on the alternative spliced isoforms of key genes that are involved in the angiogenesis process; VEGF-A, VEGFR1, VEGFR2, NRP-1, FGFRs, Vasohibin-1, Vasohibin-2, HIF-1α, Angiopoietin-1 and Angiopoietin-2.en_GB
dc.description.sponsorshipBritish Heart Foundationen_GB
dc.description.sponsorshipDiabetes UKen_GB
dc.identifier.citationVol. 20 (9) 2067en_GB
dc.identifier.doi10.3390/ijms20092067
dc.identifier.grantnumberPG/15/53/31371en_GB
dc.identifier.grantnumber17/0005668en_GB
dc.identifier.otherijms20092067
dc.identifier.urihttp://hdl.handle.net/10871/37140
dc.language.isoenen_GB
dc.publisherMDPIen_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/31027366en_GB
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_GB
dc.subjectFGFRen_GB
dc.subjectHIF-1en_GB
dc.subjectNRPen_GB
dc.subjectVEGFen_GB
dc.subjectVEGFRen_GB
dc.subjectalternative splicingen_GB
dc.subjectangiogenesisen_GB
dc.subjectangiopoietinen_GB
dc.subjectvasohibinen_GB
dc.titleAlternative Splicing in Angiogenesisen_GB
dc.typeArticleen_GB
dc.date.available2019-05-20T07:53:26Z
exeter.place-of-publicationSwitzerlanden_GB
dc.descriptionThis is the final version. Available from MDPI via the DOI in this record.en_GB
dc.identifier.journalInternational Journal of Molecular Sciencesen_GB
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2019-04-23
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2019-04-26
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2019-05-20T07:49:56Z
refterms.versionFCDVoR
refterms.dateFOA2019-05-20T07:53:29Z
refterms.panelAen_GB


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© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's licence is described as © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).