dc.contributor.author | Lear, R | |
dc.contributor.author | O'Leary, M | |
dc.contributor.author | O'Brien Andersen, L | |
dc.contributor.author | Holt, CC | |
dc.contributor.author | Stensvold, CR | |
dc.contributor.author | van der Giezen, M | |
dc.contributor.author | Bowtell, JL | |
dc.date.accessioned | 2019-05-22T10:07:28Z | |
dc.date.issued | 2019-05-13 | |
dc.description.abstract | Limited evidence suggests that the consumption of polyphenols may improve glycaemic control and insulin sensitivity. The gut microbiome produces phenolic metabolites and increases their bioavailability. A handful of studies have suggested that polyphenol consumption alters gut microbiome composition. There are no data available investigating such effects in polyphenol-rich Montmorency cherry (MC) supplementation. A total of 28 participants (aged 40-60 years) were randomized to receive daily MC or glucose and energy-matched placebo supplementation for 4 wk. Faecal and blood samples were obtained at baseline and at 4 wk. There was no clear effect of supplementation on glucose handling (Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and Gutt indices), although the Matsuda index decreased significantly in the MC group post-supplementation, reflecting an increase in serum insulin concentration. Contrastingly, placebo, but not MC supplementation induced a 6% increase in the Oral Glucose Insulin Sensitivity (OGIS) estimate of glucose clearance. Serum IL-6 and C reactive protein were unaltered by either supplement. The faecal bacterial microbiome was sequenced; species richness and diversity were unchanged by MC or placebo and no significant correlation existed between changes in Bacteroides and Faecalibacterium abundance and any index of insulin sensitivity. Therefore, 4 weeks of MC supplementation did not alter the gut microbiome, glycaemic control or systemic concentrations of IL-6 and CRP in a middle-aged population. | en_GB |
dc.description.sponsorship | The Cherry Marketing Institute | en_GB |
dc.identifier.citation | Vol. 11. No. 5 | en_GB |
dc.identifier.doi | 10.3390/nu11051063 | |
dc.identifier.uri | http://hdl.handle.net/10871/37177 | |
dc.language.iso | en | en_GB |
dc.publisher | MDPI | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/31085979 | en_GB |
dc.rights | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | en_GB |
dc.subject | Montmorency | en_GB |
dc.subject | cherry | en_GB |
dc.subject | microbiome | en_GB |
dc.subject | polyphenol | en_GB |
dc.title | Tart Cherry Concentrate Does Not Alter the Gut Microbiome, Glycaemic Control or Systemic Inflammation in a Middle-Aged Population. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2019-05-22T10:07:28Z | |
exeter.place-of-publication | Switzerland | en_GB |
dc.description | This is the final version. available from MDPI via the DOI in this record | en_GB |
dc.identifier.journal | Nutrients | en_GB |
dc.rights.uri | http://www.rioxx.net/licenses/all-rights-reserved | en_GB |
dcterms.dateAccepted | 2019-05-07 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2019-05-13 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2019-05-22T09:26:04Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2019-05-22T10:07:34Z | |
refterms.panel | A | en_GB |