dc.contributor.author | Walter, F | |
dc.contributor.author | Thompson, MJ | |
dc.contributor.author | Wellwood, I | |
dc.contributor.author | Abel, G | |
dc.contributor.author | Hamilton, W | |
dc.contributor.author | Johnson, M | |
dc.contributor.author | Lyratzopoulos, G | |
dc.contributor.author | Messenger, M | |
dc.contributor.author | Neal, R | |
dc.contributor.author | Greg, R | |
dc.contributor.author | Hardeep, S | |
dc.contributor.author | Spencer, AE | |
dc.contributor.author | Sutton, S | |
dc.contributor.author | Vedsted, P | |
dc.contributor.author | Emery, J | |
dc.date.accessioned | 2019-05-23T14:38:36Z | |
dc.date.issued | 2019-06-14 | |
dc.description.abstract | Background
Novel diagnostic triage and testing strategies to support early detection of cancer could
improve clinical outcomes. Most apparently promising diagnostic tests ultimately fail
because of inadequate performance in real‐world, low prevalence populations such as
primary care or general community populations. They should therefore be systematically
evaluated before implementation to determine whether they lead to earlier detection, are
cost‐effective, and improve patient safety and quality of care, while minimising over‐
investigation and over‐diagnosis.
Methods
We performed a systematic scoping review of frameworks for the evaluation of tests and
diagnostic approaches.
Results
We identified 16 frameworks: none addressed the entire continuum from test development
to impact on diagnosis and patient outcomes in the intended population, nor the way in
which tests may be used for triage purposes as part of a wider diagnostic strategy.
Informed by these findings, we developed a new framework, the ‘CanTest Framework’,
which proposes five iterative research phases forming a clear translational pathway from
new test development to health system implementation and evaluation.
Conclusion
This framework is suitable for testing in low prevalence populations, where tests are often
applied for triage testing and incorporated into a wider diagnostic strategy. It has relevance
for a wide range of stakeholders including patients, policymakers, purchasers, healthcare
providers and industry. | en_GB |
dc.description.sponsorship | Cancer Research UK | en_GB |
dc.description.sponsorship | NHMRC | en_GB |
dc.description.sponsorship | National Institute for Health Research (NIHR) | en_GB |
dc.description.sponsorship | Houston VA HSR&D Center for Innovations in Quality, Effectiveness and Safety | en_GB |
dc.description.sponsorship | Agency for Health Care Research and Quality | en_GB |
dc.description.sponsorship | a PCORI methods research award (Patient Centered Research on Outcomes of Diagnostic Testing | en_GB |
dc.identifier.citation | Vol. 19 (586). Published online 14 June 2019. | en_GB |
dc.identifier.doi | https://doi.org/10.1186/s12885-019-5746-6 | |
dc.identifier.grantnumber | C8640/A23385 | en_GB |
dc.identifier.grantnumber | C18081/A18180 | en_GB |
dc.identifier.grantnumber | Practitioner Fellowship | en_GB |
dc.identifier.grantnumber | CIN 13‐413 | en_GB |
dc.identifier.grantnumber | R01HS022087 | en_GB |
dc.identifier.grantnumber | ME‐1503‐29245 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/37208 | |
dc.language.iso | en | en_GB |
dc.publisher | BioMed Central | en_GB |
dc.rights | © The Author(s), 2019. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | |
dc.subject | Cancer | en_GB |
dc.subject | diagnostic strategies | en_GB |
dc.subject | early detection | en_GB |
dc.subject | diagnosis | en_GB |
dc.subject | conceptual framework | en_GB |
dc.subject | primary care | en_GB |
dc.title | Evaluating diagnostic strategies for early detection of cancer: the CanTest Framework | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2019-05-23T14:38:36Z | |
dc.identifier.issn | 1471-2407 | |
dc.description | This is the author accepted manuscript. The final version is available from BioMed Central via the DOI in this record. | en_GB |
dc.identifier.journal | BMC Cancer | en_GB |
dc.rights.uri | http://www.rioxx.net/licenses/all-rights-reserved | en_GB |
dcterms.dateAccepted | 2019-03-01 | |
rioxxterms.version | AM | en_GB |
rioxxterms.licenseref.startdate | 2019-03-01 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2019-05-23T14:30:40Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2019-06-20T13:38:47Z | |
refterms.panel | A | en_GB |