Effect of Immobilisation on Neuromuscular Function In Vivo in Humans: A Systematic Review
dc.contributor.author | Campbell, M | |
dc.contributor.author | Varley-Campbell, J | |
dc.contributor.author | Fulford, J | |
dc.contributor.author | Taylor, B | |
dc.contributor.author | Mileva, KN | |
dc.contributor.author | Bowtell, JL | |
dc.date.accessioned | 2019-06-12T09:46:25Z | |
dc.date.issued | 2019-03-21 | |
dc.description.abstract | Background: Muscle strength loss following immobilisation has been predominantly attributed to rapid muscle atrophy. However, this cannot fully explain the magnitude of muscle strength loss, so changes in neuromuscular function (NMF) may be involved. Objectives: We systematically reviewed literature that quantified changes in muscle strength, size and NMF following periods of limb immobilisation in vivo in humans. Methods: Studies were identified following systematic searches, assessed for inclusion, data extracted and quality appraised by two reviewers. Data were tabulated and reported narratively. Results: Forty eligible studies were included, 22 immobilised lower and 18 immobilised upper limbs. Limb immobilisation ranged from 12 h to 56 days. Isometric muscle strength and muscle size declined following immobilisation; however, change magnitude was greater for strength than size. Evoked resting twitch force decreased for lower but increased for upper limbs. Rate of force development either remained unchanged or slowed for lower and typically slowed for upper limbs. Twitch relaxation rate slowed for both lower and upper limbs. Central motor drive typically decreased for both locations, while electromyography amplitude during maximum voluntary contractions decreased for the lower and presented mixed findings for the upper limbs. Trends imply faster rates of NMF loss relative to size earlier in immobilisation periods for all outcomes. Conclusions: Limb immobilisation results in non-uniform loss of isometric muscle strength, size and NMF over time. Different outcomes between upper and lower limbs could be attributed to higher degrees of central neural control of upper limb musculature. Future research should focus on muscle function losses and mechanisms following acute immobilisation. Registration: PROSPERO reference: CRD42016033692. | en_GB |
dc.identifier.citation | Vol. 49 (6), pp. 931–950 | en_GB |
dc.identifier.doi | 10.1007/s40279-019-01088-8 | |
dc.identifier.uri | http://hdl.handle.net/10871/37486 | |
dc.language.iso | en | en_GB |
dc.publisher | Springer Verlag | en_GB |
dc.rights | © The Author(s) 2019. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | en_GB |
dc.title | Effect of Immobilisation on Neuromuscular Function In Vivo in Humans: A Systematic Review | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2019-06-12T09:46:25Z | |
dc.identifier.issn | 0112-1642 | |
dc.description | This is the final version. Available on open access from Springer Verlag via the DOI in this record | en_GB |
dc.description | Data Availability Statement: Data and materials are available on request from the corresponding author. | en_GB |
dc.identifier.journal | Sports Medicine | en_GB |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2019-02-26 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2019-03-21 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2019-06-11T14:52:49Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2019-06-12T09:46:30Z | |
refterms.panel | C | en_GB |
refterms.depositException | publishedGoldOA |
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This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.