Dependence on Dectin-1 Varies With Multiple Candida Species
dc.contributor.author | Thompson, A | |
dc.contributor.author | Griffiths, JS | |
dc.contributor.author | Walker, L | |
dc.contributor.author | da Fonseca, DM | |
dc.contributor.author | Lee, KK | |
dc.contributor.author | Taylor, PR | |
dc.contributor.author | Gow, NAR | |
dc.contributor.author | Orr, SJ | |
dc.date.accessioned | 2019-08-21T10:29:53Z | |
dc.date.issued | 2019-08-06 | |
dc.description.abstract | Four Candida spp. (albicans, glabrata, tropicalis, parapsilosis) cause >95% of invasive Candida infections. C. albicans elicits immune responses via pathogen recognition receptors including C-type lectin-like receptors (CLRs). The CLR, Dectin-1 is important for host immunity to C. albicans and C. glabrata, however, whether Dectin-1 is important for host defense against C. tropicalis or C. parapsilosis is unknown. Therefore, we compared the involvement of Dectin-1 in response to these four diverse Candida spp. We found that Dectin-1 mediates innate cytokine responses to these Candida spp. in a species- and cell-dependent manner. Dectin-1 KO mice succumbed to infection with highly virulent C. albicans while they mostly survived infection with less virulent Candida spp. However, Dectin-1 KO mice displayed increased fungal burden following infection with each Candida spp. Additionally, T cells from Dectin-1 KO mice displayed enhanced effector functions likely due to the inability of Dectin-1 KO mice to clear the infections. Together, these data indicate that Dectin-1 is important for host defense to multiple Candida spp., although the specific roles for Dectin-1 varies with different Candida spp. | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | Royal Society | en_GB |
dc.description.sponsorship | UK Dementia Research Institute | en_GB |
dc.description.sponsorship | MRC Centre for Medical Mycology | en_GB |
dc.identifier.citation | Vol. 10, article 1800 | en_GB |
dc.identifier.doi | 10.3389/fmicb.2019.01800 | |
dc.identifier.grantnumber | 099953/Z/12/Z | en_GB |
dc.identifier.grantnumber | 107964/Z/15/Z | en_GB |
dc.identifier.grantnumber | 086827 | en_GB |
dc.identifier.grantnumber | 075470 | en_GB |
dc.identifier.grantnumber | 097377 | en_GB |
dc.identifier.grantnumber | 101873 | en_GB |
dc.identifier.grantnumber | 200208 | en_GB |
dc.identifier.grantnumber | 093378 | en_GB |
dc.identifier.grantnumber | 099197 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/38408 | |
dc.language.iso | en | en_GB |
dc.publisher | Frontiers Media | en_GB |
dc.rights | © 2019 Thompson, Griffiths, Walker, da Fonseca, Lee, Taylor, Gow and Orr. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | en_GB |
dc.subject | Dectin-1 | en_GB |
dc.subject | Candida spp. | en_GB |
dc.subject | macrophages | en_GB |
dc.subject | dendritic cells | en_GB |
dc.subject | T cells | en_GB |
dc.title | Dependence on Dectin-1 Varies With Multiple Candida Species | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2019-08-21T10:29:53Z | |
dc.identifier.issn | 1664-302X | |
exeter.article-number | ARTN 1800 | en_GB |
dc.description | This is the final version. Available from Frontiers Media via the DOI in this record | en_GB |
dc.identifier.journal | Frontiers in Microbiology | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2019-07-22 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2019-08-06 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2019-08-21T10:16:49Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2019-08-21T10:29:57Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © 2019 Thompson, Griffiths, Walker, da Fonseca, Lee, Taylor, Gow and Orr. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.