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dc.contributor.authorVerbruggen, B
dc.contributor.authorGunnarsson, L
dc.contributor.authorKristiansson, E
dc.contributor.authorÖsterlund, T
dc.contributor.authorOwen, SF
dc.contributor.authorSnape, JR
dc.contributor.authorTyler, CR
dc.date.accessioned2019-09-13T10:09:08Z
dc.date.issued2017-11-11
dc.description.abstractPharmaceuticals are designed to interact with specific molecular targets in humans and these targets generally have orthologs in other species. This provides opportunities for the drug discovery community to use alternative model species for drug development. It also means, however, there is potential for mode of action related effects in non-target wildlife species as many pharmaceuticals reach the environment through patient use and manufacturing wastes. Acquiring insight in drug target ortholog predictions across species and taxonomic groups has proven difficult because of the lack of an optimal strategy and because necessary information is spread across multiple and diverse sources and platforms. We introduce a new research platform tool, ECOdrug, that reliably connects drugs to their protein targets across divergent species. It harmonizes ortholog predictions from multiple sources via a simple user interface underpinning critical applications for a wide range of studies in pharmacology, ecotoxicology and comparative evolutionary biology. ECOdrug can be used to identify species with drug targets and identify drugs that interact with those targets. As such, it can be applied to support intelligent targeted drug safety testing by ensuring appropriate and relevant species are selected in ecological risk assessments. ECOdrug is freely accessible and available at: Http://www.ecodrug.org.en_GB
dc.description.sponsorshipInnovative Medicines Initiative Joint Undertaking under Intelligent Assessment of Pharmaceuticalsen_GB
dc.description.sponsorshipEuropean Union’s Seventh Framework Programmeen_GB
dc.description.sponsorshipAstraZenecaen_GB
dc.description.sponsorshipNC3Rs funded projecten_GB
dc.identifier.citationVol. 46, Issue D1, pp. D930 - D936en_GB
dc.identifier.doi10.1093/nar/gkx1024
dc.identifier.grantnumber115735en_GB
dc.identifier.grantnumberFP7/2007–2013en_GB
dc.identifier.grantnumber102519en_GB
dc.identifier.urihttp://hdl.handle.net/10871/38724
dc.language.isoenen_GB
dc.publisherOxford University Pressen_GB
dc.titleECOdrug: A database connecting drugs and conservation of their targets across speciesen_GB
dc.typeArticleen_GB
dc.date.available2019-09-13T10:09:08Z
dc.identifier.issn0305-1048
dc.descriptionThis is the author accepted manuscripten_GB
dc.identifier.journalNucleic Acids Researchen_GB
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en_GB
dcterms.dateAccepted2017-10-23
rioxxterms.versionAMen_GB
rioxxterms.licenseref.startdate2017-10-23
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2019-09-13T10:01:15Z
refterms.versionFCDAM
refterms.dateFOA2019-09-13T10:09:12Z
refterms.panelAen_GB


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