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dc.contributor.authorShepherd, AI
dc.contributor.authorCostello, JT
dc.contributor.authorBailey, SJ
dc.contributor.authorBishop, NC
dc.contributor.authorWadley, AJ
dc.contributor.authorYoung-Min, S
dc.contributor.authorGilchrist, M
dc.contributor.authorMayes, H
dc.contributor.authorWhite, D
dc.contributor.authorGorczynski, P
dc.contributor.authorSaynor, ZL
dc.contributor.authorMassey, HC
dc.contributor.authorEglin, CM
dc.date.accessioned2019-09-24T13:16:01Z
dc.date.issued2019-07-25
dc.description.abstractRaynaud's phenomenon (RP) is characterised by recurrent transient peripheral vasospasm and lower nitric oxide (NO) bioavailability in the cold. We investigated the effect of nitrate-rich beetroot juice (BJ) supplementation on i) NO-mediated vasodilation, ii) cutaneous vascular conductance (CVC) and skin temperature (Tsk) following local cooling and iii) systemic anti-inflammatory status. Following baseline testing, twenty-three individuals with RP attended four times, in a double-blind, randomized crossover design, following acute and chronic (14 days) BJ and nitrate-depleted beetroot juice (NDBJ) supplementation. Peripheral Tsk and CVC were measured during and after mild hand and foot cooling, and during transdermal delivery of acetylcholine and sodium nitroprusside. Markers of anti-inflammatory status were also measured. Plasma [nitrite] was increased in the BJ conditions (P < 0.001). Compared to the baseline visit, thumb CVC was greater following chronic-BJ (Δ2.0 flux·mmHg-1, P = 0.02) and chronic-NDBJ (Δ1.45 flux·mmHg-1, P = 0.01) supplementation; however, no changes in Tsk were observed (P > 0.05). Plasma [interleukin-10] was greater, pan endothelin and systolic and diastolic blood pressure (BP) were reduced, and forearm endothelial function was improved ,by both BR and NDBJ supplementation (P < 0.05). Acute and chronic BJ and NDBJ supplementation improved anti-inflammatory status, endothelial function and BP. CVC following cooling increased post chronic-BJ and chronic-NDBJ supplementation, but no effect on Tsk was observed.en_GB
dc.description.sponsorshipNational Institute for Health Research (NIHR)en_GB
dc.identifier.citationPublished online 25 July 2019en_GB
dc.identifier.doi10.1152/japplphysiol.00292.2019
dc.identifier.grantnumberLeicester Biomedical Research Centreen_GB
dc.identifier.urihttp://hdl.handle.net/10871/38874
dc.language.isoenen_GB
dc.publisherAmerican Physiological Societyen_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/31343948en_GB
dc.rights.embargoreasonPublisher policy.en_GB
dc.rightsCopyright © 2019, Journal of Applied Physiologyen_GB
dc.subjectNitrateen_GB
dc.subjectantioxidantsen_GB
dc.subjectblood flowen_GB
dc.titleBeet the cold: Beetroot juice improves peripheral blood flow, endothelial function and anti-inflammatory status in individuals with Raynaud's phenomenon.en_GB
dc.typeArticleen_GB
dc.date.available2019-09-24T13:16:01Z
dc.identifier.issn8750-7587
exeter.place-of-publicationUnited Statesen_GB
dc.descriptionThis is the author accepted manuscript.en_GB
dc.descriptionThe final version is available from the American Physiological Society via the DOI in this record.en_GB
dc.identifier.journalJournal of Applied Physiologyen_GB
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserveden_GB
dcterms.dateAccepted2019-07-18
rioxxterms.versionAMen_GB
rioxxterms.licenseref.startdate2019-07-25
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2019-09-24T10:58:47Z
refterms.versionFCDAM
refterms.panelAen_GB


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